Varying Patterns of Biomarkers of Mineral and Bone Metabolism After Kidney Transplantation

Autor: Agnieszka Makówka, Ewa-Rutkowska Majewska, Michał Nowicki, Maciej Głyda
Rok vydání: 2017
Předmět:
Adult
Genetic Markers
Male
Fibroblast growth factor 23
medicine.medical_specialty
Time Factors
Endocrinology
Diabetes and Metabolism
Clinical Biochemistry
030232 urology & nephrology
Parathyroid hormone
030209 endocrinology & metabolism
Biochemistry
Bone remodeling
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Endocrinology
Internal medicine
Humans
Medicine
Adaptor Proteins
Signal Transducing
Creatinine
business.industry
Biochemistry (medical)
Phosphorus
Osteoblast
General Medicine
Middle Aged
Alkaline Phosphatase
medicine.disease
Kidney Transplantation
Fibroblast Growth Factors
Fibroblast Growth Factor-23
medicine.anatomical_structure
chemistry
Bone Morphogenetic Proteins
Alkaline phosphatase
Sclerostin
Calcium
Female
Secondary hyperparathyroidism
business
Biomarkers
Zdroj: Hormone and Metabolic Research. 49:618-624
ISSN: 1439-4286
0018-5043
DOI: 10.1055/s-0043-112349
Popis: Sclerostin inhibits Wnt/β-catenin signaling pathway, thereby decreasing bone formation. Osteoblast stimulating actions of parathyroid hormone (PTH) are mediated by suppression of sclerostin. Thus, sclerostin may reflect both bone metabolism and parathyroid function. The study was aimed to analyze the patterns of the changes of mineral and bone biomarkers for 9 months following kidney transplantation (KTx). Thirty-five patients after KTx were included into a 9-month observational study. Serum creatinine, calcium, phosphorus, 25-OH vitamin D, PTH, fibroblast growth factor 23 (FGF-23), sclerostin, and bone-specific alkaline phosphatase (BAP) were measured before KTx, and 1, 2 weeks, and 1, 2, 3, 4, 5, 6, and 9 months thereafter. Urine sclerostin/creatinine ratio was assessed in parallel from month 1 after KTx. Following KTx most serum markers significantly decreased till the end of observation including PTH (by 58%), phosphorus (37%), sclerostin (31%), BAP (28%), and FGF-23 (82%). Most of the decrease was observed during first 2 months after KTx. Serum calcium was increased by 17%. Urine sclerostin/creatinine ratio increased from month 1 till month 6. At KTx serum FGF-23 correlated only with phosphate (r=0.62, p=0.01) and PTH with BAP (r=0.49, p=0.04) but not with sclerostin. At the end of the study neither serum sclerostin nor FGF-23 correlated with other parameters of mineral and bone metabolism. Sclerostin shows the limited utility as the marker of the resolution of bone and mineral metabolism after KTx.
Databáze: OpenAIRE
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