An Infantile Case of Transient, Severe Hypercholesterolemia with Normalization after Complete Weaning from Breast-feeding
| Autor: | Reiko Saito, Yasusada Kawada, Koichi Kusuhara, Yukiyo Yamamoto, Rinko Kawagoe, Motohide Goto, Kazuyasu Kubo, Shunsuke Araki |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Pediatrics
medicine.medical_specialty business.industry Endocrinology Diabetes and Metabolism Physiology Case Report Familial hypercholesterolemia Breast milk medicine.disease infant Normal lipid Endocrinology breast-feeding Pediatrics Perinatology and Child Health medicine Weaning lipids (amino acids peptides and proteins) transient hypercholesterolemia business Breast feeding Mass screening Serum cholesterol Lipoprotein cholesterol |
| Zdroj: | Clinical Pediatric Endocrinology |
| ISSN: | 1347-7358 0918-5739 |
| DOI: | 10.1297/cpe.21.21 |
| Popis: | A 20-d-old boy was referred to our department because of hyperthyrotropinemia at neonatal mass screening and diagnosed with neonatal transient hyperthyrotropinemia. A follow-up examination when the patient was 5 mo old revealed severe hypercholesterolemia. Familial hypercholesterolemia was first suspected because of the patient’s significantly high levels of total and low-density lipoprotein cholesterol. The parent’s serum lipid profiles were examined and found to be normal. He was completely breast-fed until 6 mo of age. Breast milk was still the main source of food for a period following weaning. At 14 mo old, the patient was weaned completely from breast milk, and his serum cholesterol levels decreased dramatically. According to the normal lipid profiles of the patient’s parents and the spontaneous normalization of serum cholesterol levels after complete weaning from breast milk, breast-feeding was suggested to be responsible for his transient severe hypercholesterolemia. It is well documented that breast-fed infants have higher serum cholesterol levels than formula-fed infants. However, there is no reported case with severe hypercholesterolemia equivalent to or higher than the levels observed in the case of familial hypercholesterolemia. Although the exact mechanism is unknown, it is necessary to consider that a small number of cases develop severe hypercholesterolemia related to breast-feeding. |
| Databáze: | OpenAIRE |
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