Predicting positive surgical margins in partial nephrectomy: A prospective multicentre observational study (the RECORd 2 project)
| Autor: | Riccardo Schiavina, Andrea Mari, Lorenzo Bianchi, Daniele Amparore, Alessandro Antonelli, Walter Artibani, Eugenio Brunocilla, Umberto Capitanio, Cristian Fiori, Fabrizio Di Maida, Paolo Gontero, Alessandro Larcher, Vincenzo Li Marzi, Nicola Longo, Giancarlo Marra, Emanuele Montanari, Francesco Porpiglia, Marco Roscigno, Claudio Simeone, Salvatore Siracusano, Riccardo Tellini, Carlo Terrone, Donata Villari, Vincenzo Ficarra, Marco Carini, Andrea Minervini, Vincenzo Altieri, Francesco Berardinelli, Marco Borghesi, Carlo Andrea Bravi, Pierluigi Bove, Giovanni Enrico Cacciamani, Riccardo Campi, Antonio Celia, Elisabetta Costantini, Luigi Da Pozzo, Mario Falsaperla, Matteo Ferro, Maria Furlan, Simone Sforza, Francesco Marson, Francesco Montorsi, Sebastiano Nazzani, Angelo Porreca, Giorgio Ivan Russo, Luigi Schips, Cesare Selli, Alchiede Simonato, Carlo Trombetta |
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| Přispěvatelé: | Schiavina R, Mari A, Bianchi L, Amparore D, Antonelli A, Artibani W, Brunocilla E, Capitanio U, Fiori C, Di Maida F, Gontero P, Larcher A, Li Marzi V, Longo N, Marra G, Montanari E, Porpiglia F, Roscigno M, Simeone C, Siracusano S, Tellini R, Terrone C, Villari D, Ficarra V, Carini M, Minervini A, Collaborators, Schiavina R., Mari A., Bianchi L., Amparore D., Antonelli A., Artibani W., Brunocilla E., Capitanio U., Fiori C., Di Maida F., Gontero P., Larcher A., Li Marzi V., Longo N., Marra G., Montanari E., Porpiglia F., Roscigno M., Simeone C., Siracusano S., Tellini R., Terrone C., Villari D., Ficarra V., Carini M., Minervini A., Altieri V., Berardinelli F., Borghesi M., Bravi C.A., Bove P., Cacciamani G.E., Campi R., Celia A., Costantini E., Da Pozzo L., Falsaperla M., Ferro M., Furlan M., Marson F., Montorsi F., Nazzani S., Porreca A., Russo G.I., Schips L., Selli C., Simonato A., Trombetta C., Schiavina, R., Mari, A., Bianchi, L., Amparore, D., Antonelli, A., Artibani, W., Brunocilla, E., Capitanio, U., Fiori, C., Di Maida, F., Gontero, P., Larcher, A., Li Marzi, V., Longo, N., Marra, G., Montanari, E., Porpiglia, F., Roscigno, M., Simeone, C., Siracusano, S., Tellini, R., Terrone, C., Villari, D., Ficarra, V., Carini, M., Minervini, A., Altieri, V., Berardinelli, F., Borghesi, M., Bravi, C. A., Bove, P., Cacciamani, G. E., Campi, R., Celia, A., Costantini, E., Da Pozzo, L., Falsaperla, M., Ferro, M., Furlan, M., Sforza, S., Marson, F., Montorsi, F., Nazzani, S., Porreca, A., Russo, G. I., Schips, L., Selli, C., Simonato, A., Trombetta, C., Schiavina, Riccardo, Mari, Andrea, Bianchi, Lorenzo, Amparore, Daniele, Antonelli, Alessandro, Artibani, Walter, Brunocilla, Eugenio, Capitanio, Umberto, Fiori, Cristian, Di Maida, Fabrizio, Gontero, Paolo, Larcher, Alessandro, Li Marzi, Vincenzo, Longo, Nicola, Marra, Giancarlo, Montanari, Emanuele, Porpiglia, Francesco, Roscigno, Marco, Simeone, Claudio, Siracusano, Salvatore, Tellini, Riccardo, Terrone, Carlo, Villari, Donata, Ficarra, Vincenzo, Carini, Marco, Minervini, Andrea, Trombetta, Carlo |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Male
Neoplasm Residual Databases Factual multicenter prospective observational study medicine.medical_treatment 030232 urology & nephrology Nephron-sparing surgery Nephrectomy Nomogram 0302 clinical medicine Renal cell carcinoma Risk Factors clinical predictor Partial nephrectomy Prospective Studies Stage (cooking) Prospective cohort study Surgical margins Nephron-sparing surgery Nomogram Partial nephrectomy Renal cell carcinoma Robot-assisted partial nephrectomy Surgical margins Robot-assisted partial nephrectomy Margins of Excision General Medicine Middle Aged Kidney Neoplasms Hospitals Oncology Elective Surgical Procedures 030220 oncology & carcinogenesis Area Under Curve Residual Female positive surgical margin Positive Surgical Margin Elective Surgical Procedure medicine.medical_specialty Hospitals Low-Volume High-Volume 03 medical and health sciences Databases Internal medicine Low-Volume medicine Humans Neoplasm Invasiveness Carcinoma Renal Cell Factual Aged Neoplasm Staging business.industry Carcinoma Renal Cell medicine.disease Nomograms Settore MED/24 Logistic Models ROC Curve Neoplasm Surgery Observational study business Hospitals High-Volume |
| Popis: | PURPOSE: to evaluate clinical predictors of positive surgical margins (PSMs) in a large multicenter prospective observational study and to develop a clinic nomogram to predict the likelihood of PSMs after partial nephrectomy (PN). MATERIALS AND METHODS: We prospectively evaluated 4308 patients who had surgical treatment for renal tumors between January 2013 and December 2016 at 26 urological Italian Centers (RECORd 2 project). Two multivariable logistic models were evaluated to predict the likelihood of PSMs. Center caseload was dichotomized using a visual assessment adjusted for several predictors of PSMs. A nomogram predicting PSMs was developed. RESULTS: Overall, 2076 patients treated with PN were evaluated. pT1a, pT1b, pT2 and pT3a were recorded in 68.7%, 22.6%, 2.1% and 6.6% of the patients, respectively. PSMs were recorded in 342 (16.5%) patients. From a null multivariable model against number of PN/year, 60 PN/year were identified as the best cut-off to define a high-volume centre. At multivariable analysis, clinical stage (cT1a vs. cT2 [OR 1.94]; p = 0.03), volume centre (≤60 PN/year) (OR 2.22; p |
| Databáze: | OpenAIRE |
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