The changes of interleukin-2, tumour necrotic factor and gamma-interferon production among patients with Kawasaki disease
Autor: | C. Y. Lin, C. C. Lin, Betau Hwang, B. N. Chiang |
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Rok vydání: | 1991 |
Předmět: |
Male
Interleukin 2 medicine.medical_specialty Mucocutaneous Lymph Node Syndrome Gastroenterology Peripheral blood mononuclear cell Interferon-gamma Internal medicine medicine Humans Interferon gamma Vascular Diseases Child Phytohaemagglutinin Aspirin biology Tumor Necrosis Factor-alpha business.industry medicine.disease Child Preschool Pediatrics Perinatology and Child Health Immunology Leukocytes Mononuclear biology.protein Interleukin-2 Female Tumor necrosis factor alpha Kawasaki disease business medicine.drug |
Zdroj: | European Journal of Pediatrics. 150:179-182 |
ISSN: | 1432-1076 0340-6199 |
DOI: | 10.1007/bf01963561 |
Popis: | Included in this study were 43 cases of mucocutaneous lymph node syndrome (MCLS or Kawasaki disease) treated solely with aspirin. Of these, 19 developed coronary aneurysm. Mononuclear cells (MNC) of these MCLS patients were collected weekly and stimulated either with phytohaemagglutinin (PHA) or PHA plus phorbol myristic acetate. The production of interleukin-2 (IL-2), tumour necrotic factor (TNF) and gamma-interferon (IFN-r) was determined. In addition, IL-2, TNF, IFN-r from serial collections of serum samples of these patients were also measured. The results show that serum IL-2 and TNF were detected in the 1st week, reached maximal plateau in the 2nd and 3rd week and decreased 1 month later. The production of IL-2, TNF and IFN-r from MCLS patients' MNC increased from the 1st to the 3rd week, persisted at a high level for 1 month and then decreased. During the 2nd and 3rd weeks, there were significantly higher serum IL-2 levels and IL-2 production in patients with than in patients without coronary lesions. These observations suggest that the serum IL-2 level and IL-2 production during the 2nd week may serve as a predictive parameter for coronary aneurysm formation. It also suggests that the production of TNF, IL-2 and IFN-r from MNC may contribute to the development of vascular injury in acute MCLS. |
Databáze: | OpenAIRE |
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