A new method for measuring respiration in the conscious mouse
| Autor: | Kigasawa Kazuo, Tanizaki Akira, Ohkubo Kazumi, Iirino Osamu, Saitoh Kiyoshi |
|---|---|
| Rok vydání: | 1984 |
| Předmět: |
Pharmacology
Pathology medicine.medical_specialty Arachidonic Acid Morphine Morpholines Respiration Capsule Arachidonic Acids Respiratory stimulant Biology Rats Respiratory Function Tests Highly sensitive Mice DIMORPHOLAMINE medicine Animals Data recording sense organs Respiratory system Biomedical engineering medicine.drug |
| Zdroj: | Journal of Pharmacological Methods. 12:183-189 |
| ISSN: | 0160-5402 |
| DOI: | 10.1016/0160-5402(84)90058-5 |
| Popis: | A highly sensitive apparatus and method for measuring respiratory changes in conscious mice and rats is described. The apparatus is constructed from readily available components and consists of three sections: 1) mouse housing capsule and respiratory-sensitive part; 2) air supplying part; and 3) data recording part. Changes in the respiration of an encapsuled mouse can be accurately detected by means of changes in pressure exerted on the respiratory-sensitive part attached to the capsule. In our study, the rapid increases and decreases in the respiratory rates of these animals after the i.v. administration of respiratory depressing agents (morphine and arachidonate) and a respiratory stimulant (dimorpholamine) were recorded with exceptional accuracy by this procedure. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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