Role of Matricellular CCN Proteins in Skeletal Muscle: Focus on CCN2/CTGF and Its Regulation by Vasoactive Peptides
| Autor: | Daniela L. Rebolledo, Enrique Brandan, María José Acuña |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
QH301-705.5
medicine.medical_treatment cellular communication network Muscle Proteins Review Kinins Biology Catalysis Inorganic Chemistry Skeletal muscle fibrosis Renin-Angiotensin System vasoactive peptides Muscular Diseases Fibrosis CCN Intercellular Signaling Proteins medicine Animals Humans Regeneration Biology (General) Physical and Theoretical Chemistry skeletal muscle Receptor Muscle Skeletal QD1-999 Molecular Biology Spectroscopy CCN integumentary system Regeneration (biology) Growth factor Organic Chemistry fibrosis Connective Tissue Growth Factor Skeletal muscle Gene Expression Regulation Developmental General Medicine CCN2/CTGF medicine.disease KKS Computer Science Applications Cell biology CTGF Chemistry Muscular Atrophy medicine.anatomical_structure Multigene Family Peptides |
| Zdroj: | International Journal of Molecular Sciences International Journal of Molecular Sciences, Vol 22, Iss 5234, p 5234 (2021) |
| ISSN: | 1422-0067 |
| Popis: | The Cellular Communication Network (CCN) family of matricellular proteins comprises six proteins that share conserved structural features and play numerous biological roles. These proteins can interact with several receptors or soluble proteins, regulating cell signaling pathways in various tissues under physiological and pathological conditions. In the skeletal muscle of mammals, most of the six CCN family members are expressed during embryonic development or in adulthood. Their roles during the adult stage are related to the regulation of muscle mass and regeneration, maintaining vascularization, and the modulation of skeletal muscle fibrosis. This work reviews the CCNs proteins’ role in skeletal muscle physiology and disease, focusing on skeletal muscle fibrosis and its regulation by Connective Tissue Growth factor (CCN2/CTGF). Furthermore, we review evidence on the modulation of fibrosis and CCN2/CTGF by the renin-angiotensin system and the kallikrein-kinin system of vasoactive peptides. |
| Databáze: | OpenAIRE |
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