Mutations affecting retina development in Medaka
| Autor: | Felix Loosli, Rebecca Quiring, Hiroshi Suwa, Harun Elmasri, Caroline Iquel, Chikako Morinaga, Sanae Kunimatsu, Katsutoshi Niwa, Christoph Winkler, Clemens Grabher, Yukihiro Hirose, Annette Krone, Thorsten Henrich, Filippo Del Bene, Tomonori Deguchi, Beate Wittbrodt, Matthias Carl, Sylke Winkler, Akihito Yasuoka, Takao Sasado, Masakazu Osakada, Juan Ramón Martínez-Morales, Hisato Kondoh, Martina Rembold, Joachim Wittbrodt, Tomomi Watanabe, Makoto Furutani-Seiki, Hiroki Yoda, Norimasa Iwanami |
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| Přispěvatelé: | Roche, Japan Science and Technology Agency, Company of Biologists, Boehringer Ingelheim Fonds, Marie Curie Memorial Foundation, German Research Foundation, European Commission |
| Rok vydání: | 2004 |
| Předmět: |
Embryology
genetic structures Teleost Mutant Oryzias Mutagenesis (molecular biology technique) Genes Recessive Biology Optic cup (anatomical) medicine.disease_cause Eye Retina Optic vesicle formation medicine Animals Genetics Mutation Pigmentation Cell Differentiation Large scale Optic vesicle eye diseases Medaka medicine.anatomical_structure Mutagenesis sense organs Neural plate Developmental Biology |
| Zdroj: | Digital.CSIC. Repositorio Institucional del CSIC instname |
| ISSN: | 0925-4773 |
| DOI: | 10.1016/j.mod.2004.03.004 |
| Popis: | 12 páginas, 5 figuras, 1 tabla.-- et al. In a large scale mutagenesis screen of Medaka we identified 60 recessive zygotic mutations that affect retina development. Based on the onset and type of phenotypic abnormalities, the mutants were grouped into five categories: the first includes 11 mutants that are affected in neural plate and optic vesicle formation. The second group comprises 15 mutants that are impaired in optic vesicle growth. The third group includes 18 mutants that are affected in optic cup development. The fourth group contains 13 mutants with defects in retinal differentiation. 12 of these have smaller eyes, whereas one mutation results in enlarged eyes. The fifth group consists of three mutants with defects in retinal pigmentation. The collection of mutants will be used to address the molecular genetic mechanisms underlying vertebrate eye formation. This work was supported by the Roche Research Foundation (F.L.) the Japanese Agency for Science and Technology (JST) (R.Q., M.C., S.W.), the Company of Biologists Ltd (F.D.B.), the Boehringer Ingelheim Foundation (C.G.), the Marie Curie Foundation (J-R. M-M.) and through grants from the DFG, EC (J.W) and HFSP (H.K, J.W.). |
| Databáze: | OpenAIRE |
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