Antipyrine metabolism in acute hepatic porphyria in relapse and remission
| Autor: | GG Thompson, A Goldberg, MJ Brodie, GG Birnie, Moore, KE McColl |
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| Rok vydání: | 1987 |
| Předmět: |
Adult
Male Acute hepatic porphyria medicine.medical_specialty Porphyrins Adolescent Metabolic Clearance Rate Porphobilinogen Analgesic Mixed Function Oxygenases Porphyrias chemistry.chemical_compound Cytochrome P-450 Enzyme System Oral administration Internal medicine medicine Humans Pharmacology (medical) In patient Aged Pharmacology Liver Diseases Aminolevulinic Acid Metabolism Middle Aged medicine.disease Endocrinology Porphyria chemistry Female ANTIPYRINE METABOLISM Antipyrine Research Article 5-Aminolevulinate Synthetase |
| Zdroj: | British Journal of Clinical Pharmacology. 23:358-361 |
| ISSN: | 0306-5251 |
| DOI: | 10.1111/j.1365-2125.1987.tb03059.x |
| Popis: | Antipyrine kinetics following a single oral dose were obtained in porphyric patients in attack and in remission and in controls. The clearance of antipyrine was significantly lower during an acute porphyric attack (median: 0.34 ml min-1 kg-1; range: 0.1-0.71, P less than 0.05) than in patients in remission (median: 0.53 ml min-1 kg-1; range: 0.28-0.87) or controls (median: 0.52 ml min-1 kg-1; range: 0.32-0.93). There was a significant negative correlation between weight-adjusted antipyrine clearance and the urinary excretion of the porphyrin precursors, delta-aminolaevulinic acid (r = 0.86, P less than 0.001) and porphobilinogen (r = 0.82, P less than 0.002). These data suggest that the more severe the porphyric attack, the greater the impairment of hepatic monooxygenase activity. |
| Databáze: | OpenAIRE |
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