Intravenous Versus Oral Iron Supplementation for Preoperative Stimulation of Hemoglobin Synthesis Using Recombinant Human Erythropoietin
| Autor: | Christian Breymann, Roman Rohling, Axel P. Zimmermann |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Adult
medicine.medical_specialty Iron Immunology Blood Loss Surgical Administration Oral Stimulation Iron sucrose Gastroenterology Perioperative Care Hemoglobins chemistry.chemical_compound Reticulocyte Count Internal medicine medicine Humans Prospective Studies Elective surgery Erythropoietin biology business.industry Hematology Recombinant Proteins Surgery Ferritin Iron sulfate chemistry Ferritins Injections Intravenous biology.protein Erythropoiesis Hemoglobin business medicine.drug |
| Zdroj: | Journal of Hematotherapy & Stem Cell Research. 9:497-500 |
| ISSN: | 1525-8165 |
| DOI: | 10.1089/152581600419161 |
| Popis: | To compare two modalities of iron supplementation for the preoperative stimulation of erythropoiesis using recombinant human erythropoietin (rhEPO), 12 adults in normal hemoglobin and iron status due for elective surgery were randomized to rhEPO 200 U/kg body weight subcutaneously twice weekly combined with either iron sucrose 200 mg intravenously twice weekly or iron sulfate 160 mg/day orally, for 3 weeks preoperatively. Efficacy was measured by the increases over baseline in hemoglobin, reticulocyte count, and ferritin determined 3 days before surgery; preoperative reticulocyte count and ferritin were significantly higher with intravenous iron, whereas the only significant intragroup increases in hemoglobin between time points also occurred in this group. Intravenous iron significantly boosts the hematopoietic response to rhEPO and prevents iatrogenic iron depletion in otherwise healthy candidates for elective surgery. |
| Databáze: | OpenAIRE |
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