Hydrogel with silver nanoparticles synthesized by Mimosa tenuiflora for second-degree burns treatment
| Autor: | Aarón Martínez-Higuera, Eduardo Larios-Rodríguez, Juan Manuel Martínez-Soto, Ramón Iñiguez-Palomares, Ericka Rodríguez-León, Roberto Mora-Monroy, César Rodríguez-Beas, Carlos Ochoa-Sánchez, Abraham Arizmendi-Grijalva, Cristina Ibarra-Zazueta, Jesús Mauro Adolfo Villalobos-Noriega, Maria del Carmen Candia-Plata, Alfonso García-Galaz, H.A. Borbón-Nuñez, Luis Fernando López-Soto |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Mimosa tenuiflora
Male Thermogravimetric analysis Mimosa Silver Reducing agent DPPH Science Drug Evaluation Preclinical Metal Nanoparticles 02 engineering and technology 010402 general chemistry 01 natural sciences Silver nanoparticle Article chemistry.chemical_compound X-ray photoelectron spectroscopy Nanoscience and technology Animals Rats Wistar High-resolution transmission electron microscopy Wound Healing Multidisciplinary biology Chemistry Drug discovery Plant Extracts technology industry and agriculture Hydrogels 021001 nanoscience & nanotechnology biology.organism_classification Materials science 0104 chemical sciences Self-healing hydrogels Plant Bark Medicine 0210 nano-technology Burns Nuclear chemistry Phytotherapy |
| Zdroj: | Scientific Reports Scientific Reports, Vol 11, Iss 1, Pp 1-16 (2021) |
| ISSN: | 2045-2322 |
| Popis: | In this work we use Mimosa tenuiflora (MtE) extracts as reducing agents to synthesize silver nanoparticles (AgMt NPs) which were characterized by DPPH and Total Polyphenols Assays, UV–visible, X-ray diffractometer (XRD), high-resolution transmission electron microscopy (HRTEM), X-ray photoelectron spectroscopy (XPS) and Thermogravimetric analysis (TGA). AgMt NPs possess average sizes of 21 nm and fcc crystalline structure, it was also confirmed that the MtE is present in the AgMt NPs even after the cleaning protocol applied. Subsequently, carbopol hydrogels were made and the MtE and the synthesized AgMt NPs were dispersed in different gels (MtE-G and AgMt NPs-G, respectively) at 100 µg/g concentration. The gels were characterized by UV–Vis, IR, and rheology. Antimicrobial tests were performed using Staphylococcus aureus and Escherichia coli. Burn wound healing was evaluated in a second-degree burn injury on a Wistar rats model for 14 days and additional skin biopsies were examined with histopathological analysis. Gel with commercial silver nanoparticles (Ag NPs) was prepared and employed as a control on the biological assays. Hydrogel system containing silver nanoparticles synthesized with Mimosa tenuiflora (AgMt NPs-G) is a promising therapeutic strategy for burn wound healing, this due to bactericidal and anti-inflammatory effects, which promotes a more effective recovery (in percentage terms) by damaged area. |
| Databáze: | OpenAIRE |
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