Dosimetric evaluation of a simple planning method for improving intensity-modulated radiotherapy for stage III lung cancer
| Autor: | Zhu Lin, Jing Zheng, Jia-Yang Lu, Bao-Tian Huang, Pei-Xian Lin, Michael Lok-Man Cheung |
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| Rok vydání: | 2016 |
| Předmět: |
Male
Organs at Risk medicine.medical_specialty Stage III Lung Cancer Lung Neoplasms medicine.medical_treatment Dose distribution Article 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Planning method Carcinoma Non-Small-Cell Lung medicine Humans Medical physics BDPC Neoplasm Staging Multidisciplinary business.industry Radiotherapy Planning Computer-Assisted Radiotherapy Dosage Lung density Radiation therapy Conformity index Treatment Outcome 030220 oncology & carcinogenesis Female Radiotherapy Intensity-Modulated Intensity modulated radiotherapy Nuclear medicine business medicine.drug |
| Zdroj: | Scientific Reports |
| ISSN: | 2045-2322 |
| DOI: | 10.1038/srep23543 |
| Popis: | This study aimed to evaluate the dosimetric outcomes of a base-dose-plan-compensation (BDPC) planning method for improving intensity-modulated radiotherapy (IMRT) for stage III lung cancer. For each of the thirteen included patients, three types of planning methods were applied to obtain clinically acceptable plans: (1) the conventional optimization method (CO); (2) a split-target optimization method (STO), in which the optimization objectives were set higher dose for the target with lung density; (3) the BDPC method, which compensated for the optimization-convergence error by further optimization based on the CO plan. The CO, STO and BDPC methods were then compared regarding conformity index (CI), homogeneity index (HI) of the target, organs at risk (OARs) sparing and monitor units (MUs). The BDPC method provided better HI/CI by 54%/7% on average compared to the CO method and by 38%/3% compared to the STO method. The BDPC method also spared most of the OARs by up to 9%. The average MUs of the CO, STO and BDPC plans were 890, 937 and 1023, respectively. Our results indicated that the BDPC method can effectively improve the dose distribution in IMRT for stage III lung cancer, at the expense of more MUs. |
| Databáze: | OpenAIRE |
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