Unique morphogenetic signatures define mammalian neck muscles and associated connective tissues

Autor: Estelle Jullian, Alexandre Grimaldi, Marketa Tesarova, Elizabeth M. Sefton, Gabrielle Kardon, Shahragim Tajbakhsh, Jozef Kaiser, Eglantine Heude, Tomáš Zikmund, Robert G. Kelly, Noritaka Adachi
Přispěvatelé: Département Adaptations du vivant (AdV), Evolution des régulations endocriniennes (ERE), Muséum National d'Histoire Naturelle (MNHN)-Centre National de la Recherche Scientifique (CNRS)-Muséum National d'Histoire Naturelle (MNHN)-Centre National de la Recherche Scientifique (CNRS)-Mécanismes adaptatifs : des organismes aux communautés (MECADEV), Centre National de la Recherche Scientifique (CNRS)-Muséum National d'Histoire Naturelle (MNHN)-Centre National de la Recherche Scientifique (CNRS)-Muséum National d'Histoire Naturelle (MNHN)-Molécules de Communication et Adaptation des Micro-organismes (MCAM) (MCAM), Muséum National d'Histoire Naturelle (MNHN)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)-Structure et Instabilité des Génomes (STRING), Muséum National d'Histoire Naturelle (MNHN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Biologie des Organismes et Ecosystèmes Aquatiques (BOREA), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-Muséum National d'Histoire Naturelle (MNHN)-Institut de Recherche pour le Développement (IRD)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université des Antilles (UA)-Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-Institut de Recherche pour le Développement (IRD)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université des Antilles (UA), First Faculty of Medicine, Charles University [Prague], Department of Human Genetics [Salt Lake City], University of Utah, Institut de Biologie du Développement de Marseille (IBDM), Aix Marseille Université (AMU)-Collège de France (CdF)-Centre National de la Recherche Scientifique (CNRS), Cellules Souches et Développement, Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), Central European Institute of Technology [Brno, Czech Republic], Brno University of Technology [Brno], Department of Human Genetics, Département de Biologie du Développement, Institut Pasteur [Paris], Cellules Souches et Développement / Stem Cells and Development, Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), Central European Institute of Technology [Brno] (CEITEC MU), Brno University of Technology [Brno] (BUT), Aix Marseille Université (AMU)-Collège de France (CdF (institution))-Centre National de la Recherche Scientifique (CNRS), Poulain, Sébastien
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Male
0301 basic medicine
Mouse
[SDV]Life Sciences [q-bio]
Mesoderm
somite
0302 clinical medicine
Neck Muscles
Morphogenesis
Biology (General)
[SDV.BDD]Life Sciences [q-bio]/Development Biology
ComputingMilieux_MISCELLANEOUS
Mammals
Mice
Knockout
0303 health sciences
Microscopy
Confocal
Myogenesis
General Neuroscience
[SDV.BA]Life Sciences [q-bio]/Animal biology
[SDV.BID.EVO]Life Sciences [q-bio]/Biodiversity/Populations and Evolution [q-bio.PE]
030302 biochemistry & molecular biology
Gene Expression Regulation
Developmental
Neural crest
General Medicine
Cell biology
[SDV] Life Sciences [q-bio]
medicine.anatomical_structure
Somites
Connective Tissue
embryonic structures
Medicine
Female
neural crest
Research Article
TBX1
animal structures
QH301-705.5
Science
Connective tissue
Mice
Transgenic
[SDV.BC]Life Sciences [q-bio]/Cellular Biology
Biology
neck myogenesis
General Biochemistry
Genetics and Molecular Biology
03 medical and health sciences
medicine
Animals
Muscle
Skeletal
030304 developmental biology
[SDV.GEN]Life Sciences [q-bio]/Genetics
General Immunology and Microbiology
Lateral plate mesoderm
[SDV.BBM.BM]Life Sciences [q-bio]/Biochemistry
Molecular Biology/Molecular biology
X-Ray Microtomography
Somite
030104 developmental biology
cranial mesoderm
T-Box Domain Proteins
Developmental biology
030217 neurology & neurosurgery
Developmental Biology
Zdroj: eLife
eLife, eLife Sciences Publication, 2018, 7, ⟨10.7554/eLife.40179⟩
eLife, 2018, 7, pp.e40179. ⟨10.7554/eLife.40179⟩
eLife, eLife Sciences Publication, 2018, 7, pp.e40179. ⟨10.7554/eLife.40179⟩
eLife, Vol 7 (2018)
ISSN: 2050-084X
DOI: 10.7554/eLife.40179⟩
Popis: In vertebrates, head and trunk muscles develop from different mesodermal populations and are regulated by distinct genetic networks. Neck muscles at the head-trunk interface remain poorly defined due to their complex morphogenesis and dual mesodermal origins. Here, we use genetically modified mice to establish a 3D model that integrates regulatory genes, cell populations and morphogenetic events that define this transition zone. We show that the evolutionary conserved cucullaris-derived muscles originate from posterior cardiopharyngeal mesoderm, not lateral plate mesoderm, and we define new boundaries for neural crest and mesodermal contributions to neck connective tissue. Furthermore, lineage studies and functional analysis ofTbx1-andPax3-null mice reveal a unique genetic program for somitic neck muscles that is distinct from that of somitic trunk muscles. Our findings unveil the embryological and developmental requirements underlying tetrapod neck myogenesis and provide a blueprint to investigate how muscle subsets are selectively affected in some human myopathies.
Databáze: OpenAIRE
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