Efficacy of levofloxacin, amoxicillin and a proton pump inhibitor in the eradication of Helicobacter pylori in Brazilian patients with peptic ulcers
Autor: | Rejane Mattar, Ricardo C. Barbuti, Kiyoshi Iriya, Tomas Navarro-Rodriguez, Fernando Marcuz Silva, Elaine Cristina Silveira de Queiroz, Jin Hwa Lee, Jaime Natan Eisig |
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Jazyk: | angličtina |
Rok vydání: | 2015 |
Předmět: |
Adult
Male Helicobacter pylori drug effects Peptic Ulcer medicine.medical_specialty medicine.drug_class Peptic Lansoprazole Proton-pump inhibitor Gastroenterology Drug Administration Schedule Helicobacter Infections Young Adult Levofloxacin Internal medicine Clarithromycin medicine Humans Aged Aged 80 and over levofloxacin lcsh:R5-920 Helicobacter pylori biology amoxicillin therapeutic use and adverse effects business.industry Amoxicillin Proton Pump Inhibitors General Medicine Middle Aged Clinical Science biology.organism_classification digestive system diseases Anti-Bacterial Agents Surgery Regimen Breath Tests Drug Therapy Combination Female Peptic ulcer therapy business lcsh:Medicine (General) Brazil medicine.drug |
Zdroj: | Clinics; v. 70 n. 5 (2015); 318-321 Clinics; Vol. 70 Núm. 5 (2015); 318-321 Clinics; Vol. 70 No. 5 (2015); 318-321 Clinics Universidade de São Paulo (USP) instacron:USP Clinics, Vol 70, Iss 5, Pp 318-321 (2015) Clinics, Volume: 70, Issue: 5, Pages: 318-321, Published: MAY 2015 |
ISSN: | 1980-5322 1807-5932 |
Popis: | OBJECTIVES: The eradication of Helicobacter (H.) pylori allows peptic ulcers in patients infected with the bacteria to be cured. Treatment with the classic triple regimen (proton pump inhibitor, amoxicillin and clarithromycin) has shown decreased efficacy due to increased bacterial resistance to clarithromycin. In our country, the eradication rate by intention to treat with this regimen is 83%. In Brazil, a commercially available regimen for bacterial eradication that uses levofloxacin and amoxicillin with lansoprazole is available; however, its efficacy is not known. Considering that such a treatment may be an alternative to the classic regimen, we aimed to verify its efficacy in H. pylori eradication. METHODS: Patients with peptic ulcer disease infected with H. pylori who had not received prior treatment were treated with the following regimen: 30 mg lansoprazole bid, 1,000 mg amoxicillin bid and 500 mg levofloxacin, once a day for 7 days. RESULTS: A total of 66 patients were evaluated. The patients’ mean age was 52 years, and women comprised 55% of the sample. Duodenal ulcers were present in 50% of cases, and gastric ulcers were present in 30%. The eradication rate was 74% per protocol and 73% by intention to treat. Adverse effects were reported by 49 patients (74%) and were mild to moderate, with a prevalence of diarrhea complaints. CONCLUSIONS: Triple therapy comprising lansoprazole, amoxicillin and levofloxacin for 7 days for the eradication of H. pylori in Brazilian peptic ulcer patients showed a lower efficacy than that of the classic triple regimen. |
Databáze: | OpenAIRE |
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