Small left atrium and mild mitral regurgitation predict super-response to cardiac resynchronization therapy
| Autor: | Vlastimil Vančura, Kamil Sedláček, Lukáš Krýže, Daniela Černá, Josef Kautzner, Tomáš Marek, Liliana Stefan |
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| Rok vydání: | 2012 |
| Předmět: |
Male
medicine.medical_specialty Time Factors medicine.medical_treatment Population Cardiac resynchronization therapy Left atrium Ventricular Function Left Cardiac Resynchronization Therapy Text mining Physiology (medical) Internal medicine Medicine Humans Heart Atria education Aged Czech Republic Retrospective Studies Ultrasonography Heart Failure education.field_of_study Mitral regurgitation Ejection fraction Chi-Square Distribution Ventricular Remodeling business.industry Mitral Valve Insufficiency Retrospective cohort study Stroke Volume Recovery of Function Middle Aged medicine.disease medicine.anatomical_structure Logistic Models Treatment Outcome Heart failure Multivariate Analysis Cardiology Linear Models Female Cardiology and Cardiovascular Medicine business |
| Zdroj: | Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology. 14(11) |
| ISSN: | 1532-2092 |
| Popis: | Aims Cardiac resynchronization therapy (CRT) can result in profound reverse remodelling. The goal of this study was to identify factors predictive of such beneficial response. Methods and results Super-response to CRT was defined as normalization or near normalization of left ventricular systolic function without recognized reversible causes of heart failure. In a retrospective study, we compared baseline demographic, electrocardiogram, and echocardiographic characteristics of super-responders ( n = 21) with a population of unselected consecutive cardiac CRT patients (Control 1, n = 330) and another sex-, age-, and aetiology-matched control group (Control 2, n = 43). Compared with Control 1, super-responders had significantly smaller left ventricular end-diastolic diameter (65.4 ± 6.4 vs. 73.4 ± 9.3 mm, P = 0.0001), higher ejection fraction (0.25 ± 0.05 vs. 0.22 ± 0.04, P = 0.004), smaller degree of mitral regurgitation (MR; mean value 1.9 ± 0.9 vs. 2.6 ± 0.8, P = |
| Databáze: | OpenAIRE |
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