Complete remission of recurrent breast cancer with multiple liver metastases after oral capecitabine and injected trastuzumab
| Autor: | Satoko Morohashi, Hiroki Odagiri, Mutsuo Sasaki, Yutaka Kimura, Hajime Morohashi |
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| Rok vydání: | 2007 |
| Předmět: |
Adult
Oncology medicine.medical_specialty medicine.medical_treatment Administration Oral Breast Neoplasms Antibodies Monoclonal Humanized Deoxycytidine Metastasis Capecitabine Breast cancer Trastuzumab Internal medicine Antineoplastic Combined Chemotherapy Protocols medicine Humans Pharmacology (medical) Radiology Nuclear Medicine and imaging skin and connective tissue diseases Chemotherapy business.industry Carcinoma Ductal Breast Liver Neoplasms Antibodies Monoclonal Cancer Combination chemotherapy General Medicine medicine.disease Radiography Injections Intravenous Female Fluorouracil Neoplasm Recurrence Local business Epirubicin medicine.drug |
| Zdroj: | Breast Cancer. 14:297-301 |
| ISSN: | 1880-4233 1340-6868 |
| DOI: | 10.2325/jbcs.14.297 |
| Popis: | A 32-year-old woman underwent modified radical mastectomy for right breast cancer (invasive ductal carcinoma, f, INF beta, v0, ly1, pT2, pN1, M0, Stage II B ER (+/-), PR (-), Her2 (3+)) in June 2003, and received postoperative systemic adjunctive chemotherapy using epirubicin combined with cyclophosphamide, followed by paclitaxel. In August 2004, after a disease-free interval of 14 months, liver metastasis appeared, and therefore from September 2004, combination chemotherapy with oral capecitabine (2,400 mg/day) and injected trastuzumab (120 mg/week) was started. After 3 cycles, all the metastases responded and this marked response has been maintained for 16 months. This therapy is currently being continued (19 cycles), and no serious side effects have been encountered. Capesitabine and trastuzumab combination therapy is effective for recurrent breast cancer showing overexpression of HER2 and resistance to taxane, and can be considered as a first-line therapy for this purpose. It is anticipated that many cases treated with this regimen will be reported and discussed in the near future. |
| Databáze: | OpenAIRE |
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