Drug delivery in intervertebral disc degeneration and osteoarthritis: Selecting the optimal platform for the delivery of disease-modifying agents

Autor: Fabio Colella, Jacopo Oieni, Bernardo P. Antunes, Marco Sorbona, Andrea Lolli, Serdar Capar, Luana Zerrillo, Domenico D'Atri, Yunpeng Cai, J. Garcia, Sonja Häckel, Florian P.Y. Barré, M.L. Vainieri, Laura B. Creemers
Přispěvatelé: Orthopedics and Sports Medicine
Rok vydání: 2020
Předmět:
Drug
Adult
media_common.quotation_subject
Pharmaceutical Science
610 Medicine & health
02 engineering and technology
Degeneration (medical)
Osteoarthritis
Disease
Intervertebral Disc Degeneration
KNEE OSTEOARTHRITIS
Large animal-model
Bioinformatics
TRIAMCINOLONE ACETONIDE
PLATELET-RICH PLASMA
Low-back-pain
03 medical and health sciences
Drug Delivery Systems
In-vivo
FIBROBLAST GROWTH FACTOR-18
Biochemical composition
Medicine
Humans
INTRAARTICULAR INJECTION
Intervertebral Disc
030304 developmental biology
media_common
0303 health sciences
business.industry
Fibrin/hyaluronic acid hydrogel
Intervertebral disc
021001 nanoscience & nanotechnology
medicine.disease
medicine.anatomical_structure
Drug concentration
Pharmaceutical Preparations
WNT PATHWAY INHIBITOR
Drug delivery
0210 nano-technology
business
Zdroj: Colella, F, Garcia, J P, Sorbona, M, Lolli, A, Antunes, B, D'Atri, D, Barré, F P Y, Oieni, J, Vainieri, M L, Zerrillo, L, Capar, S, Häckel, S, Cai, Y & Creemers, L B 2020, ' Drug delivery in intervertebral disc degeneration and osteoarthritis : Selecting the optimal platform for the delivery of disease-modifying agents ', Journal of Controlled Release, vol. 328, pp. 985-999 . https://doi.org/10.1016/j.jconrel.2020.08.041
Colella, Fabio; Garcia, João Pedro; Sorbona, Marco; Lolli, Andrea; Antunes, Bernardo; D'Atri, Domenico; Barré, Florian P Y; Oieni, Jacopo; Vainieri, Maria Letizia; Zerrillo, Luana; Capar, Serdar; Häckel, Sonja; Cai, Yunpeng; Creemers, Laura B (2020). Drug delivery in intervertebral disc degeneration and osteoarthritis: Selecting the optimal platform for the delivery of disease-modifying agents. Journal of controlled release, 328, pp. 985-999. Elsevier 10.1016/j.jconrel.2020.08.041
Journal of Controlled Release, 328, 985-999. ELSEVIER
Journal of Controlled Release, 328, 985-999. Elsevier
J Control Release
ISSN: 0168-3659
DOI: 10.48350/149049
Popis: Osteoarthritis (OA) and intervertebral disc degeneration (IVDD) as major cause of chronic low back pain represent the most common degenerative joint pathologies and are leading causes of pain and disability in adults. Articular cartilage (AC) and intervertebral discs are cartilaginous tissues with a similar biochemical composition and pathophysiological aspects of degeneration. Although treatments directed at reversing these conditions are yet to be developed, many promising disease-modifying drug candidates are currently under investigation. Given the localized nature of these chronic diseases, drug delivery systems have the potential to enhance therapeutic outcomes by providing controlled and targeted release of bioactives, minimizing the number of injections needed and increasing drug concentration in the affected areas. This review provides a comprehensive overview of the currently most promising disease-modifying drugs as well as potential drug delivery systems for OA and IVDD therapy.
Databáze: OpenAIRE
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