Influence of PICALM and CLU risk variants on beta EEG activity in Alzheimer’s disease patients
| Autor: | Víctor Gutiérrez-de Pablo, Víctor Rodríguez-González, Aarón Maturana-Candelas, Nádia Pinto, Alexandra M. Lopes, Carlos Gómez, Jesús Poza, Roberto Hornero |
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| Přispěvatelé: | Universidad de Sevilla. Departamento de Psicología Experimental |
| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty Genotype Mathematics and computing Brain activity and meditation Science EEG connectivity Alpha (ethology) Biology Electroencephalography Article PICALM Alzheimer Disease Internal medicine Genetics medicine Humans Genetic Predisposition to Disease Neurotransmitter metabolism Allele Beta (finance) PICALM genotype Aged Aged 80 and over Multidisciplinary medicine.diagnostic_test Genetic predisposition Brain Alzheimer's disease Clusterin Endocrinology Neurology Risk factors Monomeric Clathrin Assembly Proteins Medicine Female Neuroscience |
| Zdroj: | Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021) Scientific Reports |
| ISSN: | 2045-2322 |
| Popis: | PICALM and CLU genes have been linked to alterations in brain biochemical processes that may have an impact on Alzheimer’s disease (AD) development and neurophysiological dynamics. The aim of this study is to analyze the relationship between the electroencephalographic (EEG) activity and the PICALM and CLU alleles described as conferring risk or protective effects on AD patients and healthy controls. For this purpose, EEG activity was acquired from: 18 AD patients and 12 controls carrying risk alleles of both PICALM and CLU genes, and 35 AD patients and 12 controls carrying both protective alleles. Relative power (RP) in the conventional EEG frequency bands (delta, theta, alpha, beta, and gamma) was computed to quantify the brain activity at source level. In addition, spatial entropy (SE) was calculated in each band to characterize the regional distribution of the RP values throughout the brain. Statistically significant differences in global RP and SE at beta band (p-values < 0.05, Mann–Whitney U-test) were found between genotypes in the AD group. Furthermore, RP showed statistically significant differences in 58 cortical regions out of the 68 analyzed in AD. No statistically significant differences were found in the control group at any frequency band. Our results suggest that PICALM and CLU AD-inducing genotypes are involved in physiological processes related to disruption in beta power, which may be associated with physiological disturbances such as alterations in beta-amyloid and neurotransmitter metabolism. |
| Databáze: | OpenAIRE |
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