HIV retrotransposon activity and the immunopathogenesis of AIDS
| Autor: | Emmett J. Johnson, A. Arthur Gottlieb, Robert C. Sizemore |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Microbiology (medical)
Genetics Acquired Immunodeficiency Syndrome Models Genetic Retroelements Genome Human Human immunodeficiency virus (HIV) HIV Retrotransposon Disease Biology medicine.disease_cause Immune Dysfunction medicine.disease Microbiology Virology Genome Insertional mutagenesis Mutagenesis Insertional Infectious Diseases Acquired immunodeficiency syndrome (AIDS) medicine Humans |
| Zdroj: | Trends in microbiology. 3(3) |
| ISSN: | 0966-842X |
| Popis: | This article presents the new hypothesis that HIV retrotransposon insertional mutagenesis induces genomic effects that bring about immune dysfunction through disruption, deletion or rearrangement of the genome of the host. This activity may be augmented by the action of most, if not all, the cofactors of HIV-induced disease. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect