Associations of dairy product consumption with mortality in the European Prospective Investigation into Cancer and Nutrition (EPIC)–Italy cohort
| Autor: | Fulvio Ricceri, Giovanna Masala, Francesca Fasanelli, Sara Grioni, Domenico Palli, Valeria Pala, Sabina Sieri, Graziella Frasca, Salvatore Panico, Paolo Chiodini, Rosario Tumino, Claudia Agnoli, Amalia Mattiello, Vittorio Krogh |
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| Přispěvatelé: | Pala, Valeria, Sieri, Sabina, Chiodini, Paolo, Masala, Giovanna, Palli, Domenico, Mattiello, Amalia, Panico, Salvatore, Tumino, Rosario, Frasca, Graziella, Fasanelli, Francesca, Ricceri, Fulvio, Agnoli, Claudia, Grioni, Sara, Krogh, Vittorio |
| Rok vydání: | 2019 |
| Předmět: |
Medicine (miscellaneous)
Disease 03 medical and health sciences 0302 clinical medicine cardiovascular disease Cause of Death Neoplasms Environmental health cancer Animals Humans Medicine Prospective Studies 030212 general & internal medicine Product (category theory) Proportional Hazards Models Consumption (economics) EPIC-Italy Nutrition and Dietetics business.industry Proportional hazards model Confounding Cancer Middle Aged dairy product consumption medicine.disease mortality Cardiovascular Diseases Milk Dairy Products European Prospective Investigation into Cancer and Nutrition 030220 oncology & carcinogenesis Cohort business |
| Zdroj: | The American Journal of Clinical Nutrition. 110:1220-1230 |
| ISSN: | 0002-9165 |
| DOI: | 10.1093/ajcn/nqz183 |
| Popis: | Background The relation of dairy product consumption to health and mortality is controversial. Objectives We investigated associations of consumption of various dairy products with mortality in the Italian cohort of the European Prospective Investigation into Cancer and Nutrition (EPIC)-Italy study. Methods Dairy product consumption was assessed by validated semiquantitative FFQs. Multivariable Cox models stratified by center, age, and sex and adjusted for confounders estimated associations of milk (total, full fat, and reduced fat), yogurt, cheese, butter, and dairy calcium consumption with mortality for cancer, cardiovascular disease, and all causes. Nonlinearity was tested by restricted cubic spline regression. Results After a median follow-up of 14.9 y, 2468 deaths were identified in 45,009 participants: 59% from cancer and 19% from cardiovascular disease. No significant association of consumption of any dairy product with mortality was found in the fully adjusted models. A 25% reduction in risk of all-cause mortality was found for milk intake from 160 to 120 g/d (HR: 0.75; 95% CI: 0.61, 0.91) but not for the highest (>200 g/d) category of intake (HR: 0.95; 95% CI: 0.84, 1.08) compared with nonconsumption. Associations of full-fat and reduced-fat milk consumption with all-cause and cause-specific mortality were similar to those for milk as a whole. Conclusions In this Italian cohort characterized by low to average milk consumption, we found no evidence of a dose-response association between milk consumption and mortality and also no association of consumption of other dairy products investigated with mortality. |
| Databáze: | OpenAIRE |
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