A vertebrate adaptive radiation is assembled from an ancient and disjunct spatiotemporal landscape
Autor: | Jelmer W Poelstra, Maria J Solano, Joseph A. McGirr, Jeremy Wang, Christopher Martin, Delaney C O'Connell, Bruce J. Turner, Michelle E. St. John, Emilie J. Richards |
---|---|
Rok vydání: | 2021 |
Předmět: |
Fish Proteins
Nonsynonymous substitution Genotype Bahamas Genetic Speciation Physiological Introgression adaptation Biology Polymorphism Single Nucleotide Population genomics Spatio-Temporal Analysis Adaptive radiation genomics Genetics Animals Hybrid swarm Polymorphism hybridization Phylogeny Pediatric Multidisciplinary Geography Directional selection Killifishes Gene Expression Profiling Human Genome Genomics Single Nucleotide Biological Sciences Adaptation Physiological Fixation (population genetics) Caribbean Region speciation Evolutionary biology Vertebrates Generic health relevance Adaptation adaptive radiation Genome-Wide Association Study |
Zdroj: | Proceedings of the National Academy of Sciences of the United States of America, vol 118, iss 20 Proc Natl Acad Sci U S A |
ISSN: | 1091-6490 0027-8424 |
Popis: | To investigate the origins and stages of vertebrate adaptive radiation, we reconstructed the spatial and temporal histories of adaptive alleles underlying major phenotypic axes of diversification from the genomes of 202 Caribbean pupfishes. On a single Bahamian island, ancient standing variation from disjunct geographic sources was reassembled into new combinations under strong directional selection for adaptation to the novel trophic niches of scale-eating and molluscivory. We found evidence for two longstanding hypotheses of adaptive radiation: hybrid swarm origins and temporal stages of adaptation. Using a combination of population genomics, transcriptomics, and genome-wide association mapping, we demonstrate that this microendemic adaptive radiation of novel trophic specialists on San Salvador Island, Bahamas experienced twice as much adaptive introgression as generalist populations on neighboring islands and that adaptive divergence occurred in stages. First, standing regulatory variation in genes associated with feeding behavior (prlh, cfap20, and rmi1) were swept to fixation by selection, then standing regulatory variation in genes associated with craniofacial and muscular development (itga5, ext1, cyp26b1, and galr2) and finally the only de novo nonsynonymous substitution in an osteogenic transcription factor and oncogene (twist1) swept to fixation most recently. Our results demonstrate how ancient alleles maintained in distinct environmental refugia can be assembled into new adaptive combinations and provide a framework for reconstructing the spatiotemporal landscape of adaptation and speciation. |
Databáze: | OpenAIRE |
Externí odkaz: |