Clinical pharmacology of nonsteroidal anti-inflammatory drugs in dogs
| Autor: | Butch KuKanich, Tara Bidgood, Oliver Knesl |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
musculoskeletal diseases
Ketoprofen medicine.medical_specialty Pathology Flunixin Analgesic Osteoarthritis Kidney digestive system law.invention Dogs law Internal medicine Medicine Animals Pain Management Cyclooxygenase Inhibitors Dog Diseases skin and connective tissue diseases Adverse effect Gastrointestinal tract Aspirin Clinical pharmacology General Veterinary business.industry Anti-Inflammatory Agents Non-Steroidal medicine.disease digestive system diseases Gastrointestinal Tract Liver Anesthesia business medicine.drug |
| Zdroj: | Veterinary anaesthesia and analgesia. 39(1) |
| ISSN: | 1467-2995 |
| Popis: | Objectives To discuss the clinical pharmacology of currently licensed veterinary NSAIDs and to review gastrointestinal and renal adverse effects as well as drug-drug interactions that have been reported with these drugs. To review the use of NSAIDs in the peri-operative setting and their use in patients with osteoarthritis. To further review the reported effects of NSAIDs on canine articular cartilage and liver as well as the clinical relevance of a washout period. Databases used PubMed, CAB abstracts and Google Scholar using dog, dogs, nonsteroidal anti-inflammatory drugs and NSAID(s) as keywords. Conclusions A good understanding of the mechanisms by which NSAIDs elicit their analgesic effect is essential in order to minimize adverse effects and drug-drug interactions. Cyclooxygenase (COX) is present in at least two active isoforms in the body and is the primary pharmacologic target of NSAIDs. Inhibition of COX is associated with the analgesic effects of NSAIDs. COX is present in the gastrointestinal tract and kidneys, along with other areas of the body, and is also the likely reason for many adverse effects including gastrointestinal and renal adverse effects. The newer veterinary approved NSAIDs have a lower frequency of gastrointestinal adverse effects in dogs compared to drugs such as aspirin, ketoprofen and flunixin, which may be due to differential effects on the COX isoforms. There are currently no published reports demonstrating that the newer NSAIDs are associated with fewer renal or hepatic adverse effects in dogs. NSAIDs remain the cornerstone of oral therapy for osteoarthritis unless contraindicated by intolerance, concurrent therapies or underlying medical conditions. NSAIDs are also effective and frequently used for the management of post-operative pain. |
| Databáze: | OpenAIRE |
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