Carbon dots: promising biomaterials for bone-specific imaging and drug delivery
| Autor: | Roger M. Leblanc, Patricia Blackwelder, Yiqun Zhou, Esmail H. Miyanji, Joel Pardo, Shanghao Li, Isaac Skromne, Zhili Peng, Sajini D. Hettiarachchi |
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| Rok vydání: | 2017 |
| Předmět: |
Embryo
Nonmammalian Materials science Early detection chemistry.chemical_element Biocompatible Materials Nanotechnology 02 engineering and technology 010402 general chemistry 01 natural sciences Bone and Bones Article In vivo Quantum Dots Animals General Materials Science Zebrafish Drug Carriers Carbon chemistry Binding properties 021001 nanoscience & nanotechnology Carbon 0104 chemical sciences chemistry Chemical functionalization Drug delivery 0210 nano-technology Drug carrier |
| Zdroj: | Nanoscale. 9:17533-17543 |
| ISSN: | 2040-3372 2040-3364 |
| Popis: | Bone-related diseases and dysfunctions are heavy burdens on our increasingly aged society. One important strategy to relieve this problem is through early detection and treatment of bone-related diseases. Towards this goal, there has been constant interest in developing novel bone-specific materials for imaging and drug delivery. Currently, however, materials that have high affinity and specificity towards bone are very limited. Carbon dots (C-dots) synthesized from carbon nanopowder bind to calcified bones in vivo with high affinity and specificity. In this study we show that bone binding is highly unique to a specific type of C-dot, and that this binding is non-toxic. Significantly, C-dots derived from other raw materials did not show any bone binding properties. These differences are attributed to the differences in surface chemistry of C-dot preparations, highlighting the heterogeneous nature of C-dots. Importantly, bone-binding by carbon nanopowder derived C-dots is not significantly altered by chemical functionalization of their surface. These unique properties indicate the potential applications of carbon nanopowder-derived C-dots as highly bone-specific bioimaging agents and drug carriers. |
| Databáze: | OpenAIRE |
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