Determination of Density Distribution of Tablets Using Synchrotron X-ray Computed Tomography
Autor: | Nobuto Okada, Kozo Takayama, Yasuko Obata, Naoto Yagi, Saori Otoguro, Masato Hoshino |
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Rok vydání: | 2017 |
Předmět: |
Pharmacology
Materials science Chemical Phenomena medicine.diagnostic_test Drug Compounding Finite Element Analysis Pharmaceutical Science Computed tomography Compression (physics) Synchrotron Finite element method law.invention Microcrystalline cellulose chemistry.chemical_compound Density distribution chemistry X ray computed law medicine Tomography Composite material Cellulose Tomography X-Ray Computed Synchrotrons Tablets |
Zdroj: | YAKUGAKU ZASSHI. 137:757-762 |
ISSN: | 1347-5231 0031-6903 |
Popis: | The purpose of this study was to determine the density distribution of scored and round-faced tablets using synchrotron X-ray computed tomography. The tablets were made by direct compression of standard formulations. The density distribution of scored flat-faced tablets was uniform in the whole cross-sectional image. However, the tablet formulated using microcrystalline cellulose (MCC) was very dense at the tip of the score only. It is caused by the poor fluidity of MCC particles. In the case of round-faced tablets, the density in the central section of the tablet was relatively low, compared with those of peripheral areas. These observations correlated well with the results obtained by the finite element method simulation using appropriate material models. |
Databáze: | OpenAIRE |
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