EML4-ALK fusion gene in Korean non-small cell lung cancer
| Autor: | Hyo Gyoung Kang, Sang Hoon Jheon, Hyo Sung Jeon, Seung Soo Yoo, Sung Ick Cha, Shin Yup Lee, Jae Yong Park, Guang Jin, Jae Hee Lee, Eung Bae Lee, Tae In Park, Chang Ho Kim |
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| Rok vydání: | 2011 |
| Předmět: |
Male
EML4/ALK Fusion Gene Lung Neoplasms Oncogene Proteins Fusion Biology Adenocarcinoma Brief Communication Fusion gene Exon Asian People hemic and lymphatic diseases Carcinoma Non-Small-Cell Lung Republic of Korea Correspondence medicine Carcinoma Anaplastic lymphoma kinase Humans Oncology & Hematology Non-Small-Cell Lung Lung cancer Aged Genetics Base Sequence Sequence Analysis RNA Smoking Intron General Medicine Exons EML4 Middle Aged medicine.disease Introns respiratory tract diseases ALK Cancer research Female |
| Zdroj: | Journal of Korean Medical Science |
| ISSN: | 1598-6357 |
| Popis: | A fusion gene between echinoderm microtubule-associated protein-like 4 (EML4) and the anaplastic lymphoma kinase (ALK) has been identified in non-small cell lung cancers (NSCLCs). Although a few studies have evaluated EML4-ALK fusion genes in Korean NSCLCs, the prevalence of different EML4-ALK fusion variants has yet to be clearly assessed. Herein, we have examined the profiles of EML4-ALK fusion gene variants in Korean patients of NSCLCs. EML4-ALK fusion genes have been detected in 10 (6.0%) of 167 patients of NSCLCs and in 9 (7.4%) of 121 patients of adenocarcinoma. Of the 10 patients with fusion genes identified, 8 (80%) were E13;A20 (variant 1) and 2 (20%) were E6;A20, with an additional 33-bp sequence derived from intron 6 of EML4 (variant 3b). These results indicate that the profiles of EML4-ALK fusion gene variants in Korean patients of NSCLC may differ from those in other ethnic populations. Herein, we describe for the first time the profiles of EML4-ALK fusion variants of Korean patients with NSCLCs. |
| Databáze: | OpenAIRE |
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