Class 2 Gene Expression Profile of a Hemorrhagic Pigment Epithelial Detachment Misdiagnosed as Melanoma
| Autor: | Claudine Bellerive, Arun D. Singh, Elaine Binkley |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Male
medicine.medical_specialty Pathology Lesion Diagnosis Differential 03 medical and health sciences 0302 clinical medicine Ophthalmology Biopsy Gene expression medicine Humans Diagnostic Errors Melanoma 030304 developmental biology Aged 0303 health sciences medicine.diagnostic_test business.industry Gene Expression Profiling Warfarin Retinal Detachment Atrial fibrillation medicine.disease Pigment epithelial detachment Fine-needle aspiration 030221 ophthalmology & optometry sense organs medicine.symptom business medicine.drug |
| Zdroj: | Ophthalmology. Retina. 3(5) |
| ISSN: | 2468-6530 |
| Popis: | Purpose To describe a case of a hemorrhagic pigment epithelial detachment that was initially misdiagnosed as a choroidal melanoma and had a class 2 gene expression profile (GEP) on prognostication fine needle aspiration biopsy (FNAB). Methods Retrospective case report Results A 79-year-old man with a history of atrial fibrillation treated with warfarin presented for guidance regarding systemic surveillance after undergoing prognostic FNAB at the time of episcleral plaque brachytherapy for a presumed cilio-choroidal melanoma. The results of GEP testing were consistent with a class 2 molecular profile. At three month and eight month follow up, the clinical, echographic, and optical coherence tomography (OCT) findings were consistent with a hemorrhagic pigment epithelial detachment (PED) rather than melanoma. By eight months, the lesion had completely resolved. Conclusions This is the first reported case of a GEP class 2 profile obtained from prognostic FNAB of a non-malignant lesion. Given that GEP is not a diagnostic test, it and can lead to erroneous prognostic information in the setting of non-melanoma choroidal lesions. |
| Databáze: | OpenAIRE |
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