Berberine represses Wnt/β-catenin pathway activation via modulating the microRNA-103a-3p/Bromodomain-containing protein 4 axis, thereby refraining pyroptosis and reducing the intestinal mucosal barrier defect induced via colitis

Autor:	Xun, Zhao, DeJun, Cui, WenQiang, Yuan, Chen, Chen, Qi, Liu
Rok vydání:	2022
Předmět:	Berberine Nuclear Proteins Cell Cycle Proteins Bioengineering General Medicine Colitis Applied Microbiology and Biotechnology Mice MicroRNAs Pyroptosis Animals Humans Caco-2 Cells beta Catenin Transcription Factors Biotechnology
Zdroj:	Bioengineered. 13:7392-7409
ISSN:	2165-5987 2165-5979
Popis:	Intestinal barrier dysfunction is inflammatory bowel disease's hallmark. Berberine (BBR) has manifested its anti-inflammatory properties in colitis. For exploring the molecular mechanism of BBR's impacts on colitis, application of a dextran sodium sulfate-induced mouse colitis
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72a795c53c411bf88485ad3a35576c53 https://doi.org/10.1080/21655979.2022.2047405 Zobrazit plný text záznamu