Association between alcohol dehydrogenase 1C gene *1/*2 polymorphism and pancreatitis risk: a meta-analysis
| Autor: | Jian Pan, Li-Xiao Xu, Fang Fang, Zhi-Heng Li, Guang-Hao Su, Jian Wang, Gen Li, He Zhao |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
Genotype Bioinformatics Gastroenterology Risk Factors Internal medicine Odds Ratio Genetics medicine Humans Genetic Predisposition to Disease Allele Alcohol Dehydrogenase 1C Molecular Biology Gene Alleles Polymorphism Genetic business.industry Alcohol Dehydrogenase Chronic alcoholic General Medicine Odds ratio medicine.disease Confidence interval Pancreatitis Case-Control Studies Meta-analysis business |
| Zdroj: | Genetics and Molecular Research. 14:15267-15275 |
| ISSN: | 1676-5680 |
| Popis: | Numerous studies have focused on the relationship be-tween alcohol dehydrogenase 1C gene (ADH1C) *1/*2 polymorphism (Ile350Val, rs698, also known as ADH1C *1/*2) and pancreatitis risk, but the results have been inconsistent. Thus, we conducted a meta-anal-ysis to more precisely estimate this association. Relevant publications were searched in several widely used databases and 9 eligible studies were included in the meta-analysis. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to evaluate the strength of the association. Significant associations between ADH1C *1/*2 poly-morphism and pancreatitis risk were observed in both overall meta-analysis for 12 vs 22 (OR = 1.53, 95%CI = 1.12-2.10) and 11 + 12 vs 22 (OR = 1.44, 95%CI = 1.07-1.95), and the chronic alcoholic pancre-atitis subgroup for 12 vs 22 (OR = 1.64, 95%CI = 1.17-2.29) and 11 + 12 vs 22 (OR = 1.53, 95%CI = 1.11-2.11). Significant pancreatitis risk variation was also detected in Caucasians for 11 + 12 vs 22 (OR = 1.45, 95%CI = 1.07-1.98). In conclusion, the ADH1C *1/*2 polymorphism is likely associated with pancreatitis risk, particularly chronic alcoholic pancreatitis risk, with the *1 allele functioning as a risk factor. |
| Databáze: | OpenAIRE |
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