Vascular dysfunction-The disregarded partner of Alzheimer's disease
| Autor: | Zoe Arvanitakis, Helena C. Chui, Rhian M. Touyz, Orly Lazarov, Christopher Chen, Fergus N. Doubal, Danny J.J. Wang, Lon S. Schneider, Hector M. González, Chun Yuan, Hugh S. Markus, Martin Dichgans, Gustavo C. Román, Lester R. Drewes, Anders Wallin, Deborah Gustafson, Meng Law, Rajesh N. Kalaria, Julie A. Schneider, Philip M.W. Bath, Adrian Wong, Caleb E. Finch, Axel Montagne, Sudha Seshadri, Peter Passmore, Helene Benveniste, Arthur W. Toga, Edith Hamel, Terence J. Quinn, Mark A. van Buchem, Vladimir Hachinski, David J. Werring, Sarah E. Lutz, Rebecca F. Gottesman, Berislav V. Zlokovic, Costantino Iadecola, Judy Pa, Sandra E. Black, Joel Ramirez, Ingmar Skoog, Roxana O. Carare, Majon Muller, Zvonimir S. Katusic, Perminder S. Sachdev, Steve C.R. Williams, Daniel A. Nation, Frederick Barkof, Michael A. Moskowitz, Timothy M. Hughes, Rustam Al-Shahi Salman, Joanna M. Wardlaw, Richard D. Minshall, Eric E. Smith, Jalees Rehman, Seth Love, Vincent Mok, Russell E. Jacobs, Melanie D. Sweeney, Michael G. Harrington, Cheryl L. Wellington, John T. O'Brien, Geert Jan Biessels, Monique M.B. Breteler, Stuart M. Allan, Leonardo Pantoni, Thomas P. Davis, Samuel N. Lockhart, Abhay P. Sagare |
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| Přispěvatelé: | VU University medical center, APH - Aging & Later Life, ACS - Atherosclerosis & ischemic syndromes, Internal medicine |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Aging White Matter/pathology Epidemiology Disease Neurodegenerative National Institute on Aging pathology [Alzheimer Disease] 0302 clinical medicine pathology [Brain] pathology [White Matter] Alzheimer Disease/pathology Vascular Cognitive Impairment/Dementia National Institute on Aging (U.S.) 2.1 Biological and endogenous factors Aetiology Blood-brain barrier Health Policy Brain Alzheimer's disease Cerebral blood flow White Matter Pathophysiology Psychiatry and Mental health medicine.anatomical_structure Cerebrovascular Circulation Neurological Biomarker (medicine) metabolism [Blood-Brain Barrier] Blood-Brain Barrier/metabolism MRI Amyloid Cerebrovascular Circulation/physiology Clinical Sciences metabolism [Amyloid beta-Peptides] Blood–brain barrier physiopathology [Alzheimer Disease] physiology [Cerebrovascular Circulation] Article White matter physiopathology [Vascular Diseases] 03 medical and health sciences Cellular and Molecular Neuroscience Developmental Neuroscience Alzheimer Disease Vascular Acquired Cognitive Impairment medicine Journal Article Humans Dementia Brain/pathology Vascular Diseases ddc:610 Amyloid beta-Peptides/metabolism Amyloid beta-Peptides business.industry Vascular Diseases/physiopathology Neurosciences Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD) medicine.disease United States Brain Disorders 030104 developmental biology Geriatrics Neurology (clinical) Geriatrics and Gerontology business Neuroscience 030217 neurology & neurosurgery Biomarkers |
| Zdroj: | Sweeney, M D, Montagne, A, Sagare, A P, Nation, D A, Schneider, L S, Chui, H C, Harrington, M G, Pa, J, Law, M, Wang, D J J, Jacobs, R E, Doubal, F N, Ramirez, J, Black, S E, Nedergaard, M, Benveniste, H, Dichgans, M, Iadecola, C, Love, S, Bath, P M, Markus, H S, Salman, R A, Allan, S M, Quinn, T J, Kalaria, R N, Werring, D J, Carare, R O, Touyz, R M, Williams, S C R, Moskowitz, M A, Katusic, Z S, Lutz, S E, Lazarov, O, Minshall, R D, Rehman, J, Davis, T P, Wellington, C L, González, H M, Yuan, C, Lockhart, S N, Hughes, T M, Chen, C L H, Sachdev, P, O'Brien, J T, Skoog, I, Pantoni, L, Gustafson, D R, Biessels, G J, Wallin, A, Smith, E E, Mok, V, Wong, A, Passmore, P, Barkof, F, Muller, M, Breteler, M M B, Román, G C, Hamel, E, Seshadri, S, Gottesman, R F, van Buchem, M A, Arvanitakis, Z, Schneider, J A, Drewes, L R, Hachinski, V, Finch, C E, Toga, A W, Wardlaw, J M & Zlokovic, B V 2019, ' Vascular dysfunction—The disregarded partner of Alzheimer's disease ', Alzheimer's and Dementia, vol. 15, no. 1, pp. 158-167 . https://doi.org/10.1016/j.jalz.2018.07.222 Sweeney, M D, Montagne, A, Sagare, A P, Nation, D A, Schneider, L S, Chui, H C, Harrington, M G, Pa, J, Law, M, Wang, D J J, Jacobs, R E, Doubal, F N, Ramirez, J, Black, S E, Nedergaard, M, Benveniste, H, Dichgans, M, Iadecola, C, Love, S, Bath, P M, Markus, H S, Salman, R A, Allan, S M, Quinn, T J, Kalaria, R N, Werring, D J, Carare, R O, Touyz, R M, Williams, S C R, Moskowitz, M A, Katusic, Z S, Lutz, S E, Lazarov, O, Minshall, R D, Rehman, J, Davis, T P, Wellington, C L, González, H M, Yuan, C, Lockhart, S N, Hughes, T M, Chen, C L H, Sachdev, P, Skoog, I, Pantoni, L, Gustafson, D R, Biessels, G J, Wallin, A, Mok, V, Wong, A, Passmore, P, Barkof, F, Muller, M, Breteler, M M B, Román, G C, Hamel, E, Seshadri, S, Gottesman, R F, van Buchem, M A, Arvanitakis, Z, Schneider, J A, Drewes, L R, Hachinski, V, Finch, C E, Toga, A W, Wardlaw, J M & Zlokovic, B V 2019, ' Vascular dysfunction—The disregarded partner of Alzheimer's disease ', Alzheimer's and Dementia, vol. 15, no. 1, pp. 158-167 . https://doi.org/10.1016/j.jalz.2018.07.222 Alzheimer's and Dementia, 15(1), 158-167. Elsevier Alzheimer's and Dementia, 15(1), 158-167. ELSEVIER SCIENCE INC Alzheimer's and Dementia Alzheimer's and dementia 15(1), 158-167 (2019). doi:10.1016/j.jalz.2018.07.222 Alzheimer's & dementia : the journal of the Alzheimer's Association, vol 15, iss 1 Sweeney, M D, Montagne, A, Sagare, A P, Nation, D A, Schneider, L S, Chui, H C, Harrington, M G, Pa, J, Law, M, Wang, D J J, Jacobs, R E, Doubal, F N, Ramirez, J, Black, S E, Nedergaard, M, Benveniste, H, Dichgans, M, Iadecola, C, Love, S, Bath, P M, Markus, H S, Salman, R A, Allan, S M, Quinn, T J, Kalaria, R N, Werring, D J, Carare, R O, Touyz, R M, Williams, S C R, Moskowitz, M A, Katusic, Z S, Lutz, S E, Lazarov, O, Minshall, R D, Rehman, J, Davis, T P, Wellington, C L, González, H M, Yuan, C, Lockhart, S N, Hughes, T M, Chen, C L H, Sachdev, P, O'Brien, J T, Skoog, I, Pantoni, L, Gustafson, D R, Biessels, G J, Wallin, A, Smith, E E, Mok, V, Wong, A, Passmore, P, Barkof, F, Muller, M, Breteler, M M B, Román, G C, Hamel, E, Seshadri, S, Gottesman, R F, van Buchem, M A, Arvanitakis, Z, Schneider, J A, Drewes, L R, Hachinski, V, Finch, C E, Toga, A W, Wardlaw, J M & Zlokovic, B V 2019, ' Vascular dysfunction – the disregarded partner of Alzheimer’s disease ', Alzheimer's & Dementia, vol. 15, no. 1, pp. 158-167 . https://doi.org/10.1016/j.jalz.2018.07.222 Sweeney, Melanie D; Montagne, Axel; Sagare, Abhay P; Nation, Daniel A; Schneider, Lon S; Chui, Helena C; et al.(2019). Vascular dysfunction-The disregarded partner of Alzheimer's disease.. Alzheimer's & dementia : the journal of the Alzheimer's Association, 15(1), 158-167. doi: 10.1016/j.jalz.2018.07.222. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/2fd370hr Alzheimer's & Dementia, 15(1), 158. Elsevier Inc. |
| ISSN: | 1552-5260 |
| Popis: | Increasing evidence recognizes Alzheimer's disease (AD) as a multifactorial and heterogeneous disease with multiple contributors to its pathophysiology, including vascular dysfunction. The recently updated AD Research Framework put forth by the National Institute on Aging-Alzheimer's Association describes a biomarker-based pathologic definition of AD focused on amyloid, tau, and neuronal injury. In response to this article, here we first discussed evidence that vascular dysfunction is an important early event in AD pathophysiology. Next, we examined various imaging sequences that could be easily implemented to evaluate different types of vascular dysfunction associated with, and/or contributing to, AD pathophysiology, including changes in blood-brain barrier integrity and cerebral blood flow. Vascular imaging biomarkers of small vessel disease of the brain, which is responsible for >50% of dementia worldwide, including AD, are already established, well characterized, and easy to recognize. We suggest that these vascular biomarkers should be incorporated into the AD Research Framework to gain a better understanding of AD pathophysiology and aid in treatment efforts. (C) 2018 the Alzheimer's Association. Published by Elsevier Inc. All rights reserved. |
| Databáze: | OpenAIRE |
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