Faecal immunochemical test accuracy in patients referred for surveillance colonoscopy: a multi-centre cohort study
| Autor: | Veerle M.H. Coupé, Ruud Duijkers, Jochim S. Terhaar sive Droste, Chris J. J. Mulder, René W M van der Hulst, Frank A. Oort, Lisette van der Eem, Vincent A Steeman, Gerrit A. Meijer, Sietze T. van Turenhout, Annekatrien C.T.M. Depla, Pieter Scholten, Ruud J. Loffeld, U. K. Coblijn, Anneke A. Bouman |
|---|---|
| Přispěvatelé: | Gastroenterology and hepatology, Pathology, Epidemiology and Data Science, Clinical chemistry, CCA - Oncogenesis |
| Rok vydání: | 2012 |
| Předmět: |
Adenoma
Adult Male medicine.medical_specialty Colorectal cancer Population Colonoscopy Sensitivity and Specificity Asymptomatic Gastroenterology Cohort Studies Feces Sensitivity Risk Factors Internal medicine medicine Humans Advanced adenoma Family history Faecal immunochemical test (FIT) lcsh:RC799-869 education Aged Retrospective Studies Aged 80 and over education.field_of_study Surveillance medicine.diagnostic_test Diagnostic Tests Routine business.industry Incidence Retrospective cohort study General Medicine Middle Aged medicine.disease Immunohistochemistry digestive system diseases Epidemiological Monitoring Female lcsh:Diseases of the digestive system. Gastroenterology medicine.symptom Colorectal Neoplasms business Research Article Cohort study |
| Zdroj: | Terhaar sive Droste, J S, van Turenhout, S T, Oort, F A, van der Hulst, R W M, Steeman, V A, Coblijn, U, van der Eem, L, Duijkers, R, Bouman, A A, Meijer, G A, Depla, A C T M, Scholten, P, Loffeld, R J L F, Coupé, V M H & Mulder, C J J 2012, ' Faecal immunochemical test accuracy in patients referred for surveillance colonoscopy: a multi-centre cohort study ', Bmc Gastroenterology, vol. 12, 94 . https://doi.org/10.1186/1471-230X-12-94 BMC Gastroenterology, Vol 12, Iss 1, p 94 (2012) Bmc Gastroenterology, 12:94. BioMed Central BMC Gastroenterology |
| ISSN: | 1471-230X |
| DOI: | 10.1186/1471-230X-12-94 |
| Popis: | Background Given the increasing burden on colonoscopy capacity, it has been suggested that faecal immunochemical test (FIT) results could guide surveillance colonoscopy intervals. Against this background, we have evaluated the test accuracy of single and double FIT sampling to detect colorectal cancer (CRC) and/or advanced adenomas in an asymptomatic colonoscopy-controlled high-risk population. Methods Cohort study of asymptomatic high-risk patients (personal history of adenomas/CRC or family history of CRC), who provided one or two FITs before elective colonoscopy. Test accuracy of FIT for detection of CRC and advanced adenomas was determined (cut-off level 50 ng/ml). Results 1,041 patients provided a FIT (516 personal history of adenomas, 172 personal history of CRC and 353 family history of CRC). Five CRCs (0.5%) and 101 advanced adenomas (9.7%) were detected by colonoscopy. Single FIT sampling resulted in a sensitivity, specificity, PPV and NPV for CRC of 80%, 89%, 3% and 99.9%, respectively, and for advanced adenoma of 28%, 91%, 24% and 92%, respectively. Double FIT sampling did not result in a significantly higher sensitivity for advanced neoplasia. Simulation of multiple screening rounds indicated that sensitivity of FIT for advanced adenoma could reach 81% after 5 screening rounds. Conclusions In once-only FIT sampling before surveillance colonoscopy, 70% of advanced neoplasia were missed. A simulation approach indicates that multiple screening rounds may be more promising in detecting advanced neoplasia and could potentially alleviate endoscopic burden. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink