Garidisan: Improving the Quality of Ulcer Healing in Rats with Ulcerative Colitis
| Autor: | Jian Cui, Ling-yan Pei, Lin Wang, Wei-zhi Liu, Shu-chun Li, Yu-Shi Ke |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Pathology medicine.medical_specialty Article Subject T cell Cell Andrology 03 medical and health sciences 0302 clinical medicine Immune system Intestinal mucosa Medicine Receptor business.industry lcsh:Other systems of medicine medicine.disease lcsh:RZ201-999 Ulcerative colitis Staining 030104 developmental biology medicine.anatomical_structure Complementary and alternative medicine 030211 gastroenterology & hepatology business CD8 Research Article |
| Zdroj: | Evidence-based Complementary and Alternative Medicine : eCAM Evidence-Based Complementary and Alternative Medicine, Vol 2017 (2017) |
| ISSN: | 1741-427X |
| Popis: | Garidisan, commonly used in Mongolia to treat ulcerative colitis (UC), contains wild poppy andArtemisia frigidaWilld. Clinical evidence shows that Garidisan can effectively treat UC and that recurrence is low. Thus, we evaluated the effects of Garidisan on ulcer healing quality and the regulation of immune balance in rats with experimental UC. UC was induced by immunization with TNBS and Garidisan significantly reduced DAI, CMDI, and HS. H&E staining, SEM, and VG staining showed that Garidisan repaired damaged intestinal mucosa and significantly reduced expression of ICAM-1 and CD105 in regenerated tissues of UC rats. Collagen fibers were significantly fewer as well after treatment. Garidisan elevated EGF, VEGF, bFGF, VEGFR2, and FGFR1 of UC rats, reduced CD3+CD4+/CD3+CD8+T cell ratios, and increased CD4+Th1/CD4+Th2 cell ratios and IFN-r/IL-4 ratios in peripheral blood of UC rats. In conclusion, Garidisan promoted tissue maturation of regenerated tissues by regulating the immune balance and improved functional maturity of regenerated tissues by reducing collagen formation, promoting maturation of new blood vessels, and increasing expression of growth factors and their receptors. |
| Databáze: | OpenAIRE |
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