Plasmonic gold nanostar-mediated photothermal immunotherapy for brain tumor ablation and immunologic memory
| Autor: | Peter E. Fecci, Yang Liu, Xiuyu Cui, Paolo F. Maccarini, Pakawat Chongsathidkiet, Cosette Dechant, Bridget M. Crawford, Hanna Kemeny, Tuan Vo-Dinh, Ren Odion, Christopher D. Lascola |
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| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_treatment
Short Communication Immunology Brain tumor Metal Nanoparticles 02 engineering and technology 03 medical and health sciences Mice 0302 clinical medicine Laser Interstitial Thermal Therapy medicine Immunology and Allergy Animals Nanotechnology Cancer immunology business.industry Brain Neoplasms Immunotherapy Hyperthermia Induced Neoplasms Experimental Photothermal therapy Phototherapy 021001 nanoscience & nanotechnology medicine.disease Radiation therapy Mice Inbred C57BL Oncology 030220 oncology & carcinogenesis Cancer cell Cancer research Gold Laser Therapy 0210 nano-technology business Glioblastoma Checkpoint Blockade Immunotherapy Immunologic Memory |
| Zdroj: | Immunotherapy |
| ISSN: | 1750-7448 |
| Popis: | Brain tumors present unique therapeutic challenges and they include glioblastoma (GBM) and metastases from cancers of other organs. Current treatment options are limited and include surgical resection, radiation therapy, laser interstitial thermal therapy and chemotherapy. Although much research has been done on the development of immune-based treatment platforms, only limited success has been demonstrated. Herein, we demonstrate a novel treatment of GBM through the use of plasmonic gold nanostars (GNS) as photothermal inducers for synergistic immuno photothermal nanotherapy (SYMPHONY), which combines treatments using gold nanostar and laser-induced photothermal therapy with checkpoint blockade immunotherapy. In the treatment of a murine flank tumor model with the CT-2A glioma cell line, SYMPHONY demonstrated the capability of producing long-term survivors that rejects rechallenge with cancer cells, heralding the successful emergence of immunologic memory. This study is the first to investigate the use of this novel therapy for the treatment of GBM in a murine model. |
| Databáze: | OpenAIRE |
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