Melanin-concentrating hormone (MCH) involvement in pentylenetetrazole (PTZ)-induced seizure in rat and guinea pig
| Autor: | Karl M. Knigge, Janet Wagner |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Male
medicine.medical_specialty Melanin-concentrating hormone Physiology medicine.medical_treatment Intraperitoneal injection Guinea Pigs Convulsants Biochemistry Guinea pig Rats Sprague-Dawley Cellular and Molecular Neuroscience chemistry.chemical_compound Endocrinology Species Specificity Seizures Internal medicine medicine Animals Seizure activity Oxidopamine Melanins Neurons Hypothalamic Hormones business.industry Rats Sprague dawley Pituitary Hormones nervous system chemistry Pentylenetetrazole Female business Hormone |
| Zdroj: | Peptides. 18(7) |
| ISSN: | 0196-9781 |
| Popis: | Intraperitoneal injection of 60 mg/kg of pentylenetetrazole (PTZ) induced seizure in rats, but was subthreshold and did not result in seizure in guinea pigs. Three days after intracerebroventricular (i.c.v.) injection of 75 micrograms 6-hydroxydopamine (6-OHDA) in guinea pigs, PTZ induced seizures similar to those seen in rats. In both rats and 6-OHDA-treated guinea pigs, i.c.v. injection of melanin-concentrating hormone (MCH) 15 min before PTZ prevented seizure activity. These results suggest that MCH-containing neurons may participate in the neural circuits involved in expression of PTZ-induced seizure. |
| Databáze: | OpenAIRE |
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