Electroconvulsive therapy vs. paroxetine in treatment-resistant depression — a randomized study
| Autor: | Nikolaus Michael, K. Schonauer, H. Schulze-Mönking, H. W. Folkerts, S. Mücke, R. Tölle |
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| Rok vydání: | 1997 |
| Předmět: |
Adult
Male medicine.medical_specialty Bipolar Disorder Personality Inventory medicine.medical_treatment behavioral disciplines and activities law.invention Electroconvulsive therapy Randomized controlled trial law Internal medicine mental disorders Hamd medicine Humans Treatment Failure Electroconvulsive Therapy Psychiatry Depression (differential diagnoses) Aged Depressive Disorder Major Middle Aged medicine.disease Paroxetine Psychiatry and Mental health Treatment Outcome Retreatment Antidepressive Agents Second-Generation Antidepressant Female Reuptake inhibitor Psychology Treatment-resistant depression medicine.drug |
| Zdroj: | Acta Psychiatrica Scandinavica. 96:334-342 |
| ISSN: | 1600-0447 0001-690X |
| Popis: | Failure to respond to adequate pharmacological treatment for major depression is now the most common indication for the use of electroconvulsive therapy (ECT). The advantages of ECT with respect to both speed and quality of response are clinically important issues, but surprisingly few studies have examined the efficacy of ECT in relation to newer antidepressant agents such as selective serotonin reuptake inhibitors (SSRIs). A total of 39 subjects with major depression and with at least two failed antidepressant trials (mean 4.9 trials) were randomized to either paroxetine treatment (n=18) or right unilateral (RUL) ECT (n=21). Up to the end of the study treatment we found a reduction in the HAMD score of 59% for the ECT group and of 29% for the paroxetine group (P |
| Databáze: | OpenAIRE |
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