The Anticancer and Chemopreventive Activity of Selenocyanate-Containing Compounds
| Autor: | Wesam Ali, Jadwiga Handzlik, Małgorzata Anna Marć, Noemi Salardón-Jiménez, Mónica Álvarez-Pérez, Enrique Domínguez-Álvarez |
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| Přispěvatelé: | Consejo Superior de Investigaciones Científicas (España) |
| Rok vydání: | 2018 |
| Předmět: |
Selenocyanates
Cytostaticity Cytotoxicity Pharmacology toxicology 01 natural sciences Biochemistry Chemoprevention Antioxidants 03 medical and health sciences chemistry.chemical_compound Selenium 0302 clinical medicine Pyrimidinones Drug Discovery Genetics Moiety Pharmacology Free-radical scavenging 010405 organic chemistry Diosgenin Combinatorial chemistry 0104 chemical sciences Cancer treatment Anticancer compounds chemistry 030220 oncology & carcinogenesis Functional group Cholestane |
| Zdroj: | Digital.CSIC. Repositorio Institucional del CSIC instname |
| Popis: | Purpose of the Review: The aim of this work is to review systematically the selenocyanate-containing compounds reported so far with potential applications in cancer prevention and in cancer treatment, attempting to focus on the most active selenocyanate derivatives. Recent Findings: The chemopreventive and anticancer activity of selenocyanate-containing compounds as p-xylene selenocyanate and benzyl selenocyanate was found long time ago and has been deeply studied, revealing that this functional group can affect to very different cellular and metabolic targets. In the last years, novel active compounds that combine the selenocyanate moiety with different heterocycles, quinones, or steroids have been reported, renewing the interest in this selenium-containing functional group and discovering compounds with promising properties. Generally, these compounds show antiproliferative or cytotoxic activity, although certain ones are potent antioxidant agents. The novel heterocyclic compounds are mostly substituted with a –CHSeCN moiety but longer aliphatic linkers between the ring core and the –SeCN group can be also found. Isatins, quinazolines, oxadiazoles, pyrimidinones, and tacrines can be highlighted among the heterocycles found in novel active compounds, whereas certain derivatives of diosgenin and cholestane are active steroid-containing selenocyanates. Summary: Selenocyanates are a promising class of selenocompounds that generally show interesting properties as chemopreventive or as anticancer agents. Authors would like to thank the financial support of the Spanish BAgencia Estatal Consejo Superior de Investigaciones Científicas^ (CSIC, Spanish National Research Council), through the project 201780I027. |
| Databáze: | OpenAIRE |
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