Multinuclear NMR in Polypeptide Liquid Crystals: Three Fertile Decades of Methodological Developments and Analytical Challenges

Autor: Abdelkrim Meddour, Christie Aroulanda, P. Berdagué, Denis Merlet, Jonathan Farjon, Philippe Lesot, Olivier Lafon, Nicolas Giraud
Přispěvatelé: Institut de Chimie Moléculaire et des Matériaux d'Orsay (ICMMO), Université Paris-Sud - Paris 11 (UP11)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC), Centre National de la Recherche Scientifique (CNRS), Chimie Et Interdisciplinarité : Synthèse, Analyse, Modélisation (CEISAM), Université de Nantes - UFR des Sciences et des Techniques (UN UFR ST), Université de Nantes (UN)-Université de Nantes (UN)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC), Université Paris Descartes - Paris 5 (UPD5), Unité de Catalyse et Chimie du Solide - UMR 8181 (UCCS), Centrale Lille Institut (CLIL)-Université d'Artois (UA)-Centrale Lille-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Lille, Recurrent funding (CNRS and University Paris-Sud), Université Paris-Sud - Paris 11 (UP11)-Centre National de la Recherche Scientifique (CNRS), Université de Nantes - Faculté des Sciences et des Techniques, Université de Nantes (UN)-Université de Nantes (UN)-Centre National de la Recherche Scientifique (CNRS), Unité de Catalyse et de Chimie du Solide - UMR 8181 (UCCS), Université d'Artois (UA)-Ecole Centrale de Lille-Ecole Nationale Supérieure de Chimie de Lille (ENSCL)-Université de Lille-Centre National de la Recherche Scientifique (CNRS), Université Paris-Sud - Paris 11 (UP11)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Université de Nantes (UN)-Université de Nantes (UN)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Université d'Artois (UA)-Centrale Lille-Institut de Chimie du CNRS (INC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Nuclear and High Energy Physics
Materials science
Oriented media
010402 general chemistry
01 natural sciences
Biochemistry
030218 nuclear medicine & medical imaging
Analytical Chemistry
03 medical and health sciences
0302 clinical medicine
Liquid crystal
Computational chemistry
Stereochemistry
[CHIM.ANAL]Chemical Sciences/Analytical chemistry
Analytical applications
Anisotropy
Nuclear Magnetic Resonance
Biomolecular
Spectroscopy
Quantitative Biology::Biomolecules
Anisotropic
Stereoisomerism
Nuclear magnetic resonance spectroscopy
Deuterium
NMR
Liquid Crystals
0104 chemical sciences
NMR spectra database
[CHIM.THEO]Chemical Sciences/Theoretical and/or physical chemistry
Intramolecular force
CLC
Enantiodetection
Enantiomer
Polypeptide
Peptides
Chirality (chemistry)
Magnetic dipole–dipole interaction
Zdroj: Progress in Nuclear Magnetic Resonance Spectroscopy
Progress in Nuclear Magnetic Resonance Spectroscopy, Elsevier, 2019, Progress in Nuclear Magnetic Resonance Spectroscopy, 116, pp.85-154. ⟨10.1016/j.pnmrs.2019.10.001⟩
Progress in Nuclear Magnetic Resonance Spectroscopy, Elsevier, 2019, ⟨10.1016/j.pnmrs.2019.10.001⟩
Progress in Nuclear Magnetic Resonance Spectroscopy, 2019, Progress in Nuclear Magnetic Resonance Spectroscopy, 116, pp.85-154. ⟨10.1016/j.pnmrs.2019.10.001⟩
ISSN: 0079-6565
DOI: 10.1016/j.pnmrs.2019.10.001⟩
Popis: Review on invitation by Prof. Bodenhausen; International audience; NMR spectroscopy of oriented samples makes accessible residual anisotropic intramolecular NMR interactions, such as chemical shift anisotropy (RCSA), dipolar coupling (RDC), and quadrupolar coupling (RQC), while preserving high spectral resolution. In addition, in a chiral aligned environment, enantiomers of chiral molecules or enantiopic elements of prochiral compounds adopt different average orientations on the NMR timescale, and hence produce distinct NMR spectra or signals. NMR spectroscopy in chiral aligned media is a powerful analytical tool, and notably provides unique information on (pro)chirality analysis, natural isotopic fractionation, stereochemistry, as well as molecular conformation and configuration. Significant progress has been made in this area over the three last decades, particularly using polypeptide-based chiral liquid crystals (CLCs) made of organic solutions of helically chiral polymers (as PBLG) in organic solvents. This review presents an overview of NMR in polymeric LCs. In particular, we describe the theoretical tools and the major NMR methods that have been developed and applied to study (pro)chiral molecules dissolved in such oriented solvents. We also discuss the representative applications illustrating the analytical potential of this original NMR tool. This overview article is dedicated to thirty years of original contributions to the development of NMR spectroscopy in polypeptide-based chiral liquid crystals.
Databáze: OpenAIRE
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