Potentially inappropriate medications based on TIME criteria and risk of in-hospital mortality in COVID-19 patients

Autor: Nurdan Şentürk Durmuş, Aslı Tufan, Büşra Can, Şehnaz Olgun, Derya Kocakaya, Birkan İlhan, Gülistan Bahat
Přispěvatelé: Durmuş N. Ş., Tufan A., Can B., Olgun Ş., Kocakaya D., İlhan B., Bahat G.
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Revista da Associação Médica Brasileira, Volume: 68, Issue: 12, Pages: 1730-1736, Published: 28 NOV 2022
Revista da Associação Médica Brasileira, Issue: ahead, Published: 28 NOV 2022
Revista da Associação Médica Brasileira v.68 n.12 2022
Revista da Associação Médica Brasileira
Associação Médica Brasileira (AMB)
instacron:AMB
Popis: SUMMARY OBJECTIVE: This study aimed to evaluate the relationship between hospital admission potentially inappropriate medications use (PIM) and in-hospital mortality of COVID-19, considering other possible factors related to mortality. METHODS: The Turkish inappropriate medication use in the elderly (TIME) criteria were used to define PIM. The primary outcome of this study was in-hospital mortality. RESULTS: We included 201 older adults (mean age 73.1±9.4, 48.9% females). The in-hospital mortality rate and prevalence of PIM were 18.9% (n=38) and 96% (n=193), respectively. The most common PIM according to TIME to START was insufficient vitamin D and/or calcium intake per day. Proton-pump inhibitor use for multiple drug indications was the most prevalent PIM based on TIME to STOP findings. Mortality was related to PIM in univariate analysis (p=0.005) but not in multivariate analysis (p=0.599). Older age (hazards ratio (HR): 1.08; 95% confidence interval (CI): 1.02–1.13; p=0.005) and higher Nutritional Risk Screening 2002 (NRS-2002) scores were correlated with in-hospital mortality (HR: 1.29; 95%CI 1.00–1.65; p=0.042). CONCLUSION: Mortality was not associated with PIM. Older age and malnutrition were related to in-hospital mortality in COVID-19.
Databáze: OpenAIRE
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