Multi-frequency shear modulus measurements discriminate tumorous from healthy tissues

Autor: S. Nicolle, J.-F. Palierne, D. Mitton, H. Follet, C.B. Confavreux
Přispěvatelé: Laboratoire de Biomécanique et Mécanique des Chocs (LBMC UMR T9406 ), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Gustave Eiffel, Laboratoire de Physique de l'ENS Lyon (Phys-ENS), École normale supérieure de Lyon (ENS de Lyon)-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), Physiopathologie, diagnostic et traitements des maladies osseuses / Pathophysiology, Diagnosis & Treatments of Bone Diseases (LYOS), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM), ANR-11-LABX-0063,PRIMES,Physique, Radiobiologie, Imagerie Médicale et Simulation(2011), ANR-10-LABX-0061,DEVWECAN,Development Cancer and Targeted Therapies(2010)
Rok vydání: 2023
Předmět:
Zdroj: Journal of the mechanical behavior of biomedical materials
Journal of the mechanical behavior of biomedical materials, 2023, 140, pp.105721. ⟨10.1016/j.jmbbm.2023.105721⟩
ISSN: 1751-6161
1878-0180
DOI: 10.1016/j.jmbbm.2023.105721
Popis: As far as their mechanical properties are concerned, cancerous lesions can be confused with healthy surrounding tissues in elastography protocols if only the magnitude of moduli is considered. We show that the frequency dependence of the tissue's mechanical properties allows for discriminating the tumor from other tissues, obtaining a good contrast even when healthy and tumor tissues have shear moduli of comparable magnitude. We measured the shear modulus G*(?) of xenograft subcutaneous tumors developed in mice using breast human cancer cells, compared with that of fat, skin and muscle harvested from the same mice. As the absolute shear modulus |G*(?)| of tumors increases by 42% (from 5.2 to 7.4kPa) between 0.25 and 63Hz, it varies over the same frequency range by 77% (from 0.53 to 0.94kPa) for the fat, by 103% (from 3.4 to 6.9kPa) for the skin and by 120% (from 4.4 to 9.7kPa) for the muscle. These measurements fit well to the fractional model G*(?)=K(i?)n, yielding a coefficient K and a power-law exponent n for each sample. Tumor, skin and muscle have comparable K parameter values, that of fat being significantly lower; the p-values given by a Mann-Whitney test are above 0.14 when comparing tumor, skin and muscle between themselves, but below 0.001 when comparing fat with tumor, skin or muscle. With regards the n parameter, tumor and fat are comparable, with p-values above 0.43, whereas tumor differs from both skin and muscle, with p-values below 0.001. Tumor tissues thus significantly differs from fat, skin and muscle on account of either the K or the n parameter, i.e. of either the magnitude or the frequency-dependence of the shear modulus.
Databáze: OpenAIRE
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