Astrocytes and Inflammasome: A Possible Crosstalk in Neurological Diseases
| Autor: | George E. Barreto, Morgayn I. Read, Amirhossein Sahebkar, Fahimeh Nourbakhsh |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Inflammasomes
Inflammation Disease Biochemistry Neurological Damage Glial Fibrillary Acidic Protein Drug Discovery medicine Humans Neuroinflammation Pharmacology Glial fibrillary acidic protein biology business.industry Organic Chemistry Inflammasome medicine.disease Astrogliosis Crosstalk (biology) Astrocytes biology.protein Molecular Medicine Nervous System Diseases medicine.symptom business Neuroscience medicine.drug |
| Zdroj: | Current Medicinal Chemistry. 28:4972-4994 |
| ISSN: | 0929-8673 |
| DOI: | 10.2174/0929867328666210301105422 |
| Popis: | Inflammasome research has primarily focused on neurological tissue, particularly on damaged tissue. Most current neurological literature involves in vivo and in vitro studies utilizing astroglia, as astroglia express the cytoskeletal glial fibrillary acidic protein (GFAP), which is used as a hallmark of neuropathological disorders. Research suggests that astrocytes respond to all forms of neurological damage or disease through reactive astrogliosis. Additionally, there is a consensus among scientists that inflammasomes play an important role in neuroinflammation. This review focuses on the latest developments in inflammasome biology, describing the current understanding of how inflammasomes can be triggered in the brain and summarizing the literature on the relevance of inflammasome NLR in prevalent neurological diseases. |
| Databáze: | OpenAIRE |
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