The Alpha Keto Amide Moiety as a Privileged Motif in Medicinal Chemistry: Current Insights and Emerging Opportunities
Autor: | Elisabetta Barresi, Sabrina Taliani, Emma Baglini, Marco Robello, Federico Da Settimo, Silvia Salerno |
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Jazyk: | angličtina |
Rok vydání: | 2021 |
Předmět: |
0303 health sciences
Drug discovery Chemistry Pharmaceutical Rational design Computational biology Ketones 01 natural sciences Amides 0104 chemical sciences 010404 medicinal & biomolecular chemistry 03 medical and health sciences chemistry.chemical_compound chemistry Chemical Moiety Amide Cell Line Tumor Drug Discovery Perspective Molecular Medicine Moiety Animals Humans Motif (music) 030304 developmental biology |
Zdroj: | Journal of Medicinal Chemistry |
Popis: | Over the years, researchers in drug discovery have taken advantage of the use of privileged structures to design innovative hit/lead molecules. The α-ketoamide motif is found in many natural products, and it has been widely exploited by medicinal chemists to develop compounds tailored to a vast range of biological targets, thus presenting clinical potential for a plethora of pathological conditions. The purpose of this perspective is to provide insights into the versatility of this chemical moiety as a privileged structure in drug discovery. After a brief analysis of its physical-chemical features and synthetic procedures to obtain it, α-ketoamide-based classes of compounds are reported according to the application of this motif as either a nonreactive or reactive moiety. The goal is to highlight those aspects that may be useful to understanding the perspectives of employing the α-ketoamide moiety in the rational design of compounds able to interact with a specific target. |
Databáze: | OpenAIRE |
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