Primary lymphoma of the central nervous system in two children with acquired immune deficiency syndrome
| Autor: | Annamaria Laverda, Natale Pennelli, Maurizio de Martino, Annarosa Del Mistro, Calabri Gb, C. Giaquinto, P. Cogo, Fiorella Calabrese, Rossella M. Nieri, Emma D'Andrea, Luigi Chieco-Bianchi, Salvi G, Pamela G. Kidd, Anita De Rossi, Piero Cocchi |
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| Jazyk: | angličtina |
| Rok vydání: | 1990 |
| Předmět: |
Male
Pathology medicine.medical_specialty Herpesvirus 4 Human Pediatric AIDS Central nervous system CNS lymphoma Epstein-Barr Virus [EBV] 2734 Immunoglobulins Opportunistic Infections hemic and lymphatic diseases Immunopathology HIV Seropositivity medicine Humans Epstein–Barr virus infection Gene Rearrangement Acquired Immunodeficiency Syndrome B-Lymphocytes business.industry Brain Neoplasms Lymphoma Non-Hodgkin Antibodies Monoclonal Infant General Medicine medicine.disease Immunohistochemistry Lymphoma Blotting Southern medicine.anatomical_structure Monoclonal Immunology DNA Viral Viral disease Autopsy business |
| Zdroj: | Scopus-Elsevier |
| Popis: | Postmortem examination disclosed central nervous system non-Hodgkin's lymphoma in two children who died of acquired immune deficiency syndrome (AIDS) at 6 and 14 months of age, respectively. Systemic signs of lymphoma were not present. The B-cell origin and clonality of the neoplastic cells were established by immunohistochemistry in one case and by molecular analysis of immunoglobulin gene rearrangement in the other. Moreover, in the latter case the neoplastic cells were characterized by the presence of a single episomal EBV genome. According to these data, the monoclonal B-cell proliferation occurred after EBV infection, thus suggesting a possible pathogenetic role of EBV in the early stages of lymphomagenesis. |
| Databáze: | OpenAIRE |
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