Analyses of Antioxidative Properties of Selected Cyclitols and Their Mixtures with Flavanones and Glutathione
| Autor: | Joanna Płonka, Joanna Szablińska-Piernik, Bogusław Buszewski, Irena Baranowska, Lesław B. Lahuta |
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| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
Dose-Response Relationship
Drug Molecular Structure Spectrum Analysis Pharmaceutical Science antioxidant activity Organic chemistry cyclitols Free Radical Scavengers radical-scavenging activity liquid chromatography flavonoids glutathione Article Antioxidants Gas Chromatography-Mass Spectrometry Analytical Chemistry Structure-Activity Relationship QD241-441 Chemistry (miscellaneous) Flavanones Drug Discovery Molecular Medicine Physical and Theoretical Chemistry |
| Zdroj: | Molecules, Vol 27, Iss 158, p 158 (2022) Molecules; Volume 27; Issue 1; Pages: 158 Molecules |
| ISSN: | 1420-3049 |
| Popis: | The conditions for determining the antioxidant properties of cyclitols (d-pinitol, l-quebrachitol, myo-, l-chiro-, and d-chiro-inositol), selected flavanones (hesperetin, naringenin, eriodictyol, and liquiritigenin) and glutathione by spectrophotometric methods—CUPRAC and with DPPH radical, and by a chromatographic method DPPH-UHPLC-UV, have been identified. Interactions of the tested compounds and their impact on the ox-red properties were investigated. The RSA (%) of the compounds tested was determined. Very low antioxidative properties of cyclitols, compared with flavanones and glutathione alone, were revealed. However, a significant increase in the determined antioxidative properties of glutathione by methyl-ether derivatives of cyclitols (d-pinitol and l-quebrachitol) was demonstrated for the first time. Thus, cyclitols seem to be a good candidate for creating drugs for the treatment of many diseases associated with reactive oxygen species (ROS) generation. |
| Databáze: | OpenAIRE |
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