Enzyme variability and neonatal jaundice. The role of adenosine deaminase and acid phosphatase
| Autor: | Alessandro Lepore, Nazzareno Lucarini, Paola Borgiani, P. Ballarini, G. Palombaro, Fulvia Gloria-Bottini, M. A. Evangelista, A. Londrillo, Egidio Bottini |
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| Rok vydání: | 1989 |
| Předmět: |
Male
Purine medicine.medical_specialty Adenosine Deaminase education Acid Phosphatase Population Phosphatase Nucleoside Deaminases Reductase Biology chemistry.chemical_compound Adenosine deaminase Internal medicine medicine Humans chemistry.chemical_classification education.field_of_study Polymorphism Genetic Infant Newborn Acid phosphatase Obstetrics and Gynecology Phototherapy Jaundice Jaundice Neonatal Phenotype Endocrinology Enzyme Italy chemistry Settore MED/03 - Genetica Medica Pediatrics Perinatology and Child Health biology.protein Female medicine.symptom |
| Zdroj: | Scopus-Elsevier |
| DOI: | 10.18452/10982 |
| Popis: | A sample of children treated by phototherapy during the neonatal period has been studied in the population of Penne (South Eastern Italy) in order to confirm the association previously reported in newborns from the population of Rome between neonatal jaundice and phenotypes of adenosine deaminase (ADA) and acid phosphatase (ACP1). The present data confirm that the incidence of clinically relevant jaundice is much greater in newborns of phenotype ACP1 BA carrying ADA2 allele than in other infants. Since ACP1 probably acts as flavin mononucleotide phosphatase and is modulated by purine nucleotides, it is likely that enzymes of purine nucleotide metabolism (including ADA), ACP1 and flavoenzymes (including gluthatione reductase and enzymes of Krebs cycle), may represent a polygenic complex influencing bilirubin levels in the first few days of life. |
| Databáze: | OpenAIRE |
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