Adoptive cellular therapies: the current landscape
| Autor: | Maartje W. Rohaan, John B. A. G. Haanen, Sofie Wilgenhof |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
medicine.medical_treatment Review Article Immunotherapy Adoptive Tumor-infiltrating lymphocytes Pathology and Forensic Medicine Cell therapy 03 medical and health sciences 0302 clinical medicine Immune system Lymphocytes Tumor-Infiltrating Neoplasms medicine Tumor Microenvironment Humans Chimeric antigen receptor Molecular Biology Receptors Chimeric Antigen business.industry T-cell receptor Cancer Cell Biology General Medicine Immunotherapy medicine.disease Immune checkpoint Adoptive cell therapy 030104 developmental biology 030220 oncology & carcinogenesis Cancer research T cell receptor business |
| Zdroj: | Virchows Archiv |
| ISSN: | 1432-2307 0945-6317 |
| Popis: | For many cancer types, the immune system plays an essential role in their development and growth. Based on these rather novel insights, immunotherapeutic strategies have been developed. In the past decade, immune checkpoint blockade has demonstrated a major breakthrough in cancer treatment and has currently been approved for the treatment of multiple tumor types. Adoptive cell therapy (ACT) with tumor-infiltrating lymphocytes (TIL) or gene-modified T cells expressing novel T cell receptors (TCR) or chimeric antigen receptors (CAR) is another strategy to modify the immune system to recognize tumor cells and thus carry out an anti-tumor effector function. These treatments have shown promising results in various tumor types, and multiple clinical trials are being conducted worldwide to further optimize this treatment modality. Most successful results were obtained in hematological malignancies with the use of CD19-directed CAR T cell therapy and already led to the commercial approval by the FDA. This review provides an overview of the developments in ACT, the associated toxicity, and the future potential of ACT in cancer treatment. |
| Databáze: | OpenAIRE |
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