Naples Prognostic Score: A Novel Prognostic Score in Predicting Cancer-Specific Survival in Patients With Resected Esophageal Squamous Cell Carcinoma
Autor: | Sheng Chen, Qi-Xun Chen, Ji-Feng Feng, Jian-Ming Zhao |
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Jazyk: | angličtina |
Rok vydání: | 2021 |
Předmět: |
Oncology
medicine.medical_specialty Cancer Research Multivariate analysis medicine.medical_treatment education Cancer specific survival Prognostic score 03 medical and health sciences 0302 clinical medicine cancer-specific survival Internal medicine lymphocyte to monocyte ratio medicine In patient Neutrophil to lymphocyte ratio neutrophil to lymphocyte ratio Neoadjuvant therapy RC254-282 Original Research Receiver operating characteristic business.industry Naples prognostic score Neoplasms. Tumors. Oncology. Including cancer and carcinogens Nomogram esophageal squamous cell carcinoma 030220 oncology & carcinogenesis 030211 gastroenterology & hepatology prognosis business |
Zdroj: | Frontiers in Oncology Frontiers in Oncology, Vol 11 (2021) |
ISSN: | 2234-943X |
Popis: | BackgroundNaples prognostic score (NPS) serves as a new prognostic index based on nutritional and inflammatory status in recent years. The aim of the current study was to explore the prognostic effect of NPS and to develop and validate a reliable nomogram based on NPS for individual cancer-specific survival (CSS) prediction in patients with resected ESCC without neoadjuvant therapy.MethodsThe clinical data for 287 (Jan. 2010 to Jun. 2012, Training sets) and 118 (Jan. 2015 to Dec 2015, Validation sets) consecutive resected ESCC cases were retrospectively analyzed. Two NPS models based on the different cut-off values of parameters were compared. Cut-off values in model 1 were derived from previous published studies, while cut-off values in model 2 were obtained in this study based on receiver operating characteristic (ROC) curves. The relationships between NPS and clinical characteristics and CSS were analyzed. The prediction model of nomogram was developed with independent prognostic factors in the training sets and was validated in the validation sets.ResultsThe 5-year CSS for NPS 0, 1 and 2 were 61.9%, 34.6% and 13.4% in model 1 and 75.0%, 42.4% and 13.0% in model 2, respectively (PConclusionThe current study confirmed that NPS was still a useful independent prognostic score in patients with resected ESCC. The NPS-based nomogram was successfully developed and validated, which may contribute to individual CSS prediction for resected ESCC patients. |
Databáze: | OpenAIRE |
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