Expression of the neonatal Fc receptor (FcRn) in the bovine mammary gland
| Autor: | Laszlo V. Frenyo, Zsuzsanna Bosze, Márton Doleschall, Imre Kacskovics, János Bartyik, Balázs Mayer, Balázs Bender |
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| Rok vydání: | 2005 |
| Předmět: |
medicine.medical_specialty
Mammary gland Gene Expression Receptors Fc In situ hybridization Biology Immunoglobulin E Andrology Mammary Glands Animal Neonatal Fc receptor Pregnancy Internal medicine Lactation medicine Animals Tissue Distribution Receptor In Situ Hybridization Reverse Transcriptase Polymerase Chain Reaction Colostrum Parturition Biological Transport Epithelial Cells General Medicine Immunohistochemistry medicine.anatomical_structure Endocrinology Animals Newborn Immunoglobulin G biology.protein Cattle Female Animal Science and Zoology Antibody Food Science |
| Zdroj: | Journal of Dairy Research. 72:107-112 |
| ISSN: | 1469-7629 0022-0299 |
| DOI: | 10.1017/s0022029905001135 |
| Popis: | In ruminants, protective immunoglobulins are transferred to the newborn via colostrum to mediate maternal immunity. There is a high selectivity in the transport of immunoglobulins from the maternal plasma across the mammary barrier into the colostrum, and only IgG1 is transferred in large amounts. We have recently analysed the expression of the neonatal Fc receptor (FcRn) in sheep mammary gland around parturition. Re-analysing this issue in bovine confirmed our previous data indicating that FcRn is homogeneously localized in the mammary gland acinar cells before parturition, however a remarkable difference was observed in the pattern after calving, where only the apical side of the cells was strongly stained. The presence of the FcRn in the acinar epithelial cells of the mammary gland and the obvious change in distribution before and after parturition indicate that FcRn plays an important role in the IgG transport during colostrum formation in ruminants. |
| Databáze: | OpenAIRE |
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