Natriuretic Peptides as Predictors of Cardiovascular Events and All-Cause Mortality
| Autor: | Martin A. Alpert |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Cardiac biomarkers business.industry Peptide Fragments Article Blood pressure Cardiovascular Diseases Internal medicine Natriuretic Peptide Brain medicine Cardiology Humans cardiovascular diseases Cardiology and Cardiovascular Medicine business Natriuretic Peptides All cause mortality hormones hormone substitutes and hormone antagonists |
| Zdroj: | J Am Coll Cardiol |
| ISSN: | 1558-3597 |
| Popis: | BACKGROUND: Although intensive blood pressure reduction has cardiovascular benefits, the absolute benefit is greater in those at higher cardiovascular disease (CVD) risk. OBJECTIVE: We examined whether NT-proBNP helps identify individuals at higher risk for CVD events across systolic blood pressure (SBP), diastolic blood pressure (DBP) or pulse pressure (PP) categories. METHODS: Participants from ARIC study visit 4 (1996–98) were grouped according to SBP, DBP or PP categories and further stratified by NT-proBNP categories. Cox regression models were used to estimate hazard ratios for incident CVD (CHD, ischemic stroke or HF hospitalization) and mortality across combined NT-proBNP/BP categories adjusting for CVD risk factors. RESULTS: There were 9,309 participants (mean age 62.6 [SD 5.6] years, 58.3 % females) with 2,416 CVD events over a median follow-up of 16.7 years. Within each SBP, DBP or PP category, higher category of NT-proBNP (100 |
| Databáze: | OpenAIRE |
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