A preliminary metabolic study of alpidem in rat and man
| Autor: | P.L. Morselli, S. Vajta, J P Thenot, P. Guinebault, P Padovani, A Durand, J. Allen |
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| Rok vydání: | 1987 |
| Předmět: |
Adult
Male Imidazopyridine medicine.drug_class Stereochemistry Pyridines Biology Ring (chemistry) Anxiolytic Biotransformation Species Specificity medicine Side chain Metabolic study Animals Bile Humans Pharmacology (medical) Pharmacology Imidazoles Rats Inbred Strains Metabolism Rats Alpidem medicine.drug |
| Zdroj: | European journal of drug metabolism and pharmacokinetics. 12(4) |
| ISSN: | 0378-7966 |
| Popis: | The metabolism of alpidem, a new anxiolytic agent in the chemical series of imidazopyridines, was investigated in rat and man. In both species the compound is extensively metabolised by three main routes of biotransformation: aromatic oxidation of the imidazopyridine ring; n-dealkylation; and/or aliphatic oxidation of the substituted amide side chains. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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