Prevalence of Thyroid Dysfunction in Autoimmune and Type 2 Diabetes: The Population-Based HUNT Study in Norway

Autor: Trine Bjøro, Hanne Fiskvik Fleiner, Bjørn Olav Åsvold, Kristian Midthjell, Valdemar Grill
Rok vydání: 2015
Předmět:
Adult
Male
medicine.medical_specialty
Thyroid Hormones
endocrine system diseases
Databases
Factual
Cross-sectional study
Endocrinology
Diabetes and Metabolism
Clinical Biochemistry
Population
030209 endocrinology & metabolism
Context (language use)
Type 2 diabetes
medicine.disease_cause
Biochemistry
Hyperthyroidism
Iodide Peroxidase
Autoimmunity
03 medical and health sciences
0302 clinical medicine
Endocrinology
Sex Factors
Hypothyroidism
Internal medicine
Diabetes mellitus
medicine
Prevalence
Humans
030212 general & internal medicine
Age of Onset
education
Aged
education.field_of_study
business.industry
Norway
Biochemistry (medical)
Middle Aged
medicine.disease
Thyroid Diseases
Confidence interval
Cross-Sectional Studies
Diabetes Mellitus
Type 1
Diabetes Mellitus
Type 2
Female
Age of onset
business
Zdroj: The Journal of clinical endocrinology and metabolism. 101(2)
ISSN: 1945-7197
Popis: Associations between autoimmune diabetes and autoimmune thyroid disease are known but insufficiently characterized. Some evidence suggests that type 2 diabetes may also be associated with hypothyroidism.The objective of the study was to investigate associations of autoimmune and type 2 diabetes with the prevalence of hypo- and hyperthyroidism.This was a cross-sectional, population-based study of adults in two surveys of the Nord-Trøndelag Health (HUNT) Study.A total of 34 235 participants of HUNT2 (1995-1997) and 48 809 participants of HUNT3 (2006-2008) participated in the study.Prevalence of hypo- and hyperthyroidism was estimated, assessed by self-report, serum measurements, and linkage with the Norwegian Prescription Database.In HUNT2, autoimmune diabetes was associated with a higher age-adjusted prevalence of hypothyroidism among both women (prevalence ratio 1.79, 95% confidence interval [CI] 1.30-2.47) and men (prevalence ratio 2.71, 95% CI 1.76-4.19), compared with having no diabetes. For hyperthyroidism, the corresponding cumulative prevalence ratios were 2.12 (95% CI 1.36-3.32) in women and 2.54 (95% CI 1.24-5.18) in men with autoimmune diabetes. The age-adjusted excess prevalence of hypothyroidism (∼6 percentage points) and the presence of thyroid peroxidase antibodies (8-10 percentage points) associated with autoimmune diabetes was similar in women and men. Type 2 diabetes was not associated with the prevalence of hypothyroidism. In HUNT3, associations were broadly similar to those in HUNT2.Autoimmune diabetes, but not type 2 diabetes, was strongly and gender neutrally associated with an increased prevalence of hypo- and hyperthyroidism and the presence of thyroid peroxidase antibodies. Increased surveillance for hypothyroidism appears not necessary in patients with type 2 diabetes.
Databáze: OpenAIRE
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