Paraneoplastic Limbic Encephalitis Complicated with Small Cell Lung Cancer at the Time of Recurrence
| Autor: | Koichiro Takahashi, Hiroki Tashiro, Yuki Kurihara, Haruki Hirakawa, Tomomi Nakamura, Naoko Sueoka-Aragane, Shinsuke Ogusu, Hironori Sadamatsu, Kazutoshi Komiya, Chiho Nakashima |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Oncology medicine.medical_specialty medicine.medical_treatment Case Report Paraneoplastic limbic encephalitis Metastatic tumor lcsh:RC254-282 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Lung cancer Chemotherapy biology Small cell lung cancer business.industry lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens medicine.disease respiratory tract diseases 030104 developmental biology 030220 oncology & carcinogenesis biology.protein Anti-amphiphysin antibody Non small cell Antibody business Amrubicin Glucocorticoid medicine.drug Anti-glutamic acid decarboxylase antibody |
| Zdroj: | Case Reports in Oncology Case Reports in Oncology, Vol 12, Iss 2, Pp 466-472 (2019) |
| ISSN: | 1662-6575 |
| Popis: | Paraneoplastic limbic encephalitis (PLE) is a rare neurologic disorder that can complicate various malignancies, including lung cancer. PLE is most frequently found the initial presentation of lung cancer. In this study, we reported the case of a 74-year-old Japanese woman who developed PLE after partial remission of small cell lung cancer (SCLC) by first-line systemic chemotherapy. Brain magnetic resonance imaging showed no metastatic tumor or cerebrovascular disease. Anti-glutamic acid decarboxylase (GAD) and anti-amphiphysin antibodies were detected in her serum. She was diagnosed as having PLE related to the recurrence of SCLC and received high-dose glucocorticoid, and sequentially systemic chemotherapy with amrubicin. Unfortunately, these treatments did not improve her disease progression and she died 4 months later. Although PLE rarely occurs at the time of SCLC recurrence, physicians should pay attention to PLE onset even after chemotherapy. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
| Nepřihlášeným uživatelům se plný text nezobrazuje | K zobrazení výsledku je třeba se přihlásit. |