Neuropilin 1 is expressed on thymus-derived natural regulatory T cells, but not mucosa-generated induced Foxp3+ T reg cells
| Autor: | Jonathan M. Weiss, Michael L. Dustin, Soyoung Oh, Huizhong Xiong, Christopher N. Parkhurst, Alexander Y. Rudensky, Yi Ding, Yi Yang, Juan J. Lafaille, Rachel E. Niec, Dan R. Littman, Alan B. Frey, Maria A. Curotto de Lafaille, Stefan Floess, Jayashree Dolpady, Maria Grazia Ruocco, Angelina M. Bilate, Ming O. Li, Jochen Huehn, Michael Gobert |
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| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Cell type
Immunology Inflammation chemical and pharmacologic phenomena Mice Transgenic Thymus Gland Biology Lymphocyte Activation T-Lymphocytes Regulatory Article 03 medical and health sciences Mice 0302 clinical medicine Immune system Lymphocytes Tumor-Infiltrating In vivo immune system diseases Transforming Growth Factor beta hemic and lymphatic diseases Neuropilin 1 medicine Immunology and Allergy Animals Cell Lineage Intestinal Mucosa 030304 developmental biology Regulation of gene expression 0303 health sciences Mucous Membrane Cell Membrane FOXP3 hemic and immune systems Forkhead Transcription Factors Transforming growth factor beta Molecular biology Neuropilin-1 3. Good health Intestines Gene Expression Regulation biology.protein Metagenome medicine.symptom 030215 immunology |
| Zdroj: | The Journal of Experimental Medicine |
| Popis: | Neuropilin-1 surface expression discriminates between nT reg cells with stable expression and Nrp1 low iT reg cells showing inducible expression under inflammatory conditions. Foxp3 activity is essential for the normal function of the immune system. Two types of regulatory T (T reg) cells express Foxp3, thymus-generated natural T reg (nT reg) cells, and peripherally generated adaptive T reg (iT reg) cells. These cell types have complementary functions. Until now, it has not been possible to distinguish iT reg from nT reg cells in vivo based solely on surface markers. We report here that Neuropilin 1 (Nrp1) is expressed at high levels by most nT reg cells; in contrast, mucosa-generated iT reg and other noninflammatory iT reg cells express low levels of Nrp1. We found that Nrp1 expression is under the control of TGF-β. By tracing nT reg and iT reg cells, we could establish that some tumors have a very large proportion of infiltrating iT reg cells. iT reg cells obtained from highly inflammatory environments, such as the spinal cords of mice with spontaneous autoimmune encephalomyelitis (EAE) and the lungs of mice with chronic asthma, express Nrp1. In the same animals, iT reg cells in secondary lymphoid organs remain Nrp1low. We also determined that, in spontaneous EAE, iT reg cells help to establish a chronic phase of the disease. |
| Databáze: | OpenAIRE |
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